Depression in palliative care: a systematic review. Part 2. Treatment
Depression in palliative care: a systematic review. Part 2. Treatment
Objective: To summarize available literature containing data on the treatment of depression in palliative care patients.
Methods: A systematic review was conducted using extensive electronic databases and hand searches. All randomized controlled trials (RCTs) of interventions for depression in patients with advanced disease were eligible.
Results: Three RCTs assessed pharmacological treatments. Of these, two were placebo controlled and assessed mianserin and thioridazine. The third compared two antidepressants. There were no RCTs that specifically assessed psychotherapy for patients with depression.
Conclusion: There are too few adequate studies to draw clear conclusions about management of depression in this setting. The treatment of depression in patients with advanced disease must, for now, be informed by the larger body of evidence on effective treatments for depression in patients with either no physical illness or less severe medical conditions.
advanced cancer, depression, depressive disorder, intervention, palliative care, treatment
279-284
Ly, K.L.
87560cc4-7562-4f9b-b908-81f3b603fdd8
Chidgey, J.
7c9efdfc-0ecd-4c10-a7c3-a1e34e556ee1
Hotopf, M.
2cbaf083-846d-4471-aa5d-49b67a114173
1 June 2002
Ly, K.L.
87560cc4-7562-4f9b-b908-81f3b603fdd8
Chidgey, J.
7c9efdfc-0ecd-4c10-a7c3-a1e34e556ee1
Hotopf, M.
2cbaf083-846d-4471-aa5d-49b67a114173
Ly, K.L., Chidgey, J. and Hotopf, M.
(2002)
Depression in palliative care: a systematic review. Part 2. Treatment.
Palliative Medicine, 16 (4), .
(doi:10.1191/0269216302pm570oa).
Abstract
Objective: To summarize available literature containing data on the treatment of depression in palliative care patients.
Methods: A systematic review was conducted using extensive electronic databases and hand searches. All randomized controlled trials (RCTs) of interventions for depression in patients with advanced disease were eligible.
Results: Three RCTs assessed pharmacological treatments. Of these, two were placebo controlled and assessed mianserin and thioridazine. The third compared two antidepressants. There were no RCTs that specifically assessed psychotherapy for patients with depression.
Conclusion: There are too few adequate studies to draw clear conclusions about management of depression in this setting. The treatment of depression in patients with advanced disease must, for now, be informed by the larger body of evidence on effective treatments for depression in patients with either no physical illness or less severe medical conditions.
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Published date: 1 June 2002
Keywords:
advanced cancer, depression, depressive disorder, intervention, palliative care, treatment
Identifiers
Local EPrints ID: 11123
URI: http://eprints.soton.ac.uk/id/eprint/11123
ISSN: 0269-2163
PURE UUID: 2b8e2866-6e43-4d2c-968f-15ad98a266ad
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Date deposited: 28 Oct 2004
Last modified: 15 Mar 2024 05:02
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Author:
J. Chidgey
Author:
M. Hotopf
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