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Nutrient control of TORC1, a cell-cycle regulator

Nutrient control of TORC1, a cell-cycle regulator
Nutrient control of TORC1, a cell-cycle regulator
It is well established that the target of rapamycin (TOR) protein kinase has pivotal roles in controlling cell functions (including protein synthesis, cell growth and cell proliferation) and is implicated in numerous human diseases. Mammalian TOR complex 1 (mTORC1) signalling is activated by hormones and growth factors, and is also stimulated by intracellular amino acids. Recent research has provided important new insight into the poorly understood mechanism by which amino acids activate mTORC1 signalling, showing that the protein kinase MAP4K3 and Rag GTPases have important roles in this. mTORC1 is known to control the G1/S transition of the cell cycle: new data show that (m)TORC1 also controls G2/M progression in yeast and mammals, albeit in contrasting ways
0962-8924
260-267
Wang, Xuemin
d6bb4eb2-5687-46ed-b770-cceb22fd792e
Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3
Wang, Xuemin
d6bb4eb2-5687-46ed-b770-cceb22fd792e
Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3

Wang, Xuemin and Proud, Christopher G. (2009) Nutrient control of TORC1, a cell-cycle regulator. Trends in Cell Biology, 19 (6), 260-267. (doi:10.1016/j.tcb.2009.03.005).

Record type: Article

Abstract

It is well established that the target of rapamycin (TOR) protein kinase has pivotal roles in controlling cell functions (including protein synthesis, cell growth and cell proliferation) and is implicated in numerous human diseases. Mammalian TOR complex 1 (mTORC1) signalling is activated by hormones and growth factors, and is also stimulated by intracellular amino acids. Recent research has provided important new insight into the poorly understood mechanism by which amino acids activate mTORC1 signalling, showing that the protein kinase MAP4K3 and Rag GTPases have important roles in this. mTORC1 is known to control the G1/S transition of the cell cycle: new data show that (m)TORC1 also controls G2/M progression in yeast and mammals, albeit in contrasting ways

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Published date: June 2009

Identifiers

Local EPrints ID: 142735
URI: http://eprints.soton.ac.uk/id/eprint/142735
ISSN: 0962-8924
PURE UUID: 3533e216-cbdd-49b6-b576-ce4ef8656bba

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Date deposited: 01 Apr 2010 14:16
Last modified: 14 Mar 2024 00:41

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Contributors

Author: Xuemin Wang
Author: Christopher G. Proud

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