BADASP: predicting functional specificity in protein families using ancestral sequences
BADASP: predicting functional specificity in protein families using ancestral sequences
Burst After Duplication with Ancestral Sequence Predictions (BADASP) is a software package for identifying sites that may confer subfamily-specific biological functions in protein families following functional divergence of duplicated proteins. A given protein phylogeny is grouped into subfamilies based on orthology/paralogy relationships and/or user definitions. Ancestral sequences are then predicted from the sequence alignment and the functional specificity is calculated using variants of the Burst After Duplication method, which tests for radical amino acid substitutions following gene duplications that are subsequently conserved. Statistics are output along with subfamily groupings and ancestral sequences for an easy analysis with other packages
4190-4191
Edwards, Richard J.
9d25e74f-dc0d-455a-832c-5f363d864c43
Shields, D.C.
57ffee4f-0277-4b3d-9c7a-8c328637d8e6
November 2005
Edwards, Richard J.
9d25e74f-dc0d-455a-832c-5f363d864c43
Shields, D.C.
57ffee4f-0277-4b3d-9c7a-8c328637d8e6
Edwards, Richard J. and Shields, D.C.
(2005)
BADASP: predicting functional specificity in protein families using ancestral sequences.
Bioinformatics, 21 (22), .
(doi:10.1093/bioinformatics/bti678).
Abstract
Burst After Duplication with Ancestral Sequence Predictions (BADASP) is a software package for identifying sites that may confer subfamily-specific biological functions in protein families following functional divergence of duplicated proteins. A given protein phylogeny is grouped into subfamilies based on orthology/paralogy relationships and/or user definitions. Ancestral sequences are then predicted from the sequence alignment and the functional specificity is calculated using variants of the Burst After Duplication method, which tests for radical amino acid substitutions following gene duplications that are subsequently conserved. Statistics are output along with subfamily groupings and ancestral sequences for an easy analysis with other packages
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Published date: November 2005
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Local EPrints ID: 143475
URI: http://eprints.soton.ac.uk/id/eprint/143475
ISSN: 1367-4803
PURE UUID: 29517349-e376-45af-a0f6-5fce8bf980d5
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Date deposited: 30 Jun 2010 13:47
Last modified: 14 Mar 2024 00:43
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Author:
Richard J. Edwards
Author:
D.C. Shields
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