DNA vaccines against cancer come of age
DNA vaccines against cancer come of age
Genetic technology allows construction of DNA vaccines encoding selected tumor antigens together with molecules to direct and amplify the desired effector pathways. Their enormous promise has been marred by a problem of scaling up to human subjects. This is now largely overcome by electroporation, which increases both antigen expression and the inflammatory milieu. While the principles of vaccine design can be developed in mouse models, the real operative test is in the clinic, using patients in temporary remission. Monitoring of induced immunity, although commonly limited to blood, is providing objective qualitative and quantitative data on T-cell and antibody responses. Prolongation of remission is the goal and an activated immune system should achieve this
264-270
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
Rice, Jason
d58d4fcd-8dc0-4599-bf96-62323d579227
April 2010
Stevenson, Freda K.
ba803747-c0ac-409f-a9c2-b61fde009f8c
Ottensmeier, Christian H.
42b8a398-baac-4843-a3d6-056225675797
Rice, Jason
d58d4fcd-8dc0-4599-bf96-62323d579227
Stevenson, Freda K., Ottensmeier, Christian H. and Rice, Jason
(2010)
DNA vaccines against cancer come of age.
Current Opinion in Immunology, 22 (2), .
(doi:10.1016/j.coi.2010.01.019).
Abstract
Genetic technology allows construction of DNA vaccines encoding selected tumor antigens together with molecules to direct and amplify the desired effector pathways. Their enormous promise has been marred by a problem of scaling up to human subjects. This is now largely overcome by electroporation, which increases both antigen expression and the inflammatory milieu. While the principles of vaccine design can be developed in mouse models, the real operative test is in the clinic, using patients in temporary remission. Monitoring of induced immunity, although commonly limited to blood, is providing objective qualitative and quantitative data on T-cell and antibody responses. Prolongation of remission is the goal and an activated immune system should achieve this
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Published date: April 2010
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Local EPrints ID: 143637
URI: http://eprints.soton.ac.uk/id/eprint/143637
ISSN: 0952-7915
PURE UUID: 42f3014c-0534-418d-abec-48c29c170b98
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Date deposited: 12 Apr 2010 13:40
Last modified: 14 Mar 2024 02:40
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Jason Rice
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