Relation of exhaled nitric oxide levels to development of bronchopulmonary dysplasia

May, C. Williams, O., Milner, A.D., Peacock, J., Rafferty, G.F., Hannam, S. and Greenough, A. (2009) Relation of exhaled nitric oxide levels to development of bronchopulmonary dysplasia. Archives of Disease in Childhood Fetal Neonatal Edition, 94, (3), F205-F209. (doi:10.1136/adc.2008.146589).


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Objective: to test the hypothesis that exhaled nitric
oxide levels on day 28 and changes in exhaled nitric oxide
levels in the neonatal period would differ according to
whether infants developed bronchopulmonary dysplasia
(BPD) and its severity.

Design: prospective observational study.

Setting: tertiary neonatal intensive care unit.

Patients: 80 infants (median gestational age 28, range
24–32 weeks), 46 of whom developed BPD.

Interventions: exhaled nitric oxide measurements were
attempted on days 3, 5, 7, 14, 21 and 28.
Main outcome measures: BPD (oxygen dependency at
28 days), mild BPD (oxygen dependent at 28 days, but
not 36 weeks postmenstrual age (PMA)); moderate BPD
(oxygen dependent at 36 weeks PMA) and severe BPD
(respiratory support dependent at 36 weeks PMA).

Results: on day 28, exhaled nitric oxide levels were
higher in infants with BPD compared to those without BPD
(p,0.001) and there was a linear trend in exhaled nitric
oxide results as BPD severity increased (p=0.006). No
significances in the change in exhaled nitric oxide levels
over the neonatal period were found between the four

Conclusion: exhaled nitric oxide levels are raised in
infants with established BPD, particularly in those
developing moderate or severe BPD, and may reflect
ongoing inflammation.

Item Type: Article
ISSNs: 1359-2998 (print)
1468-2052 (electronic)
Related URLs:
Subjects: R Medicine > R Medicine (General)
Divisions: University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
ePrint ID: 143667
Date Deposited: 12 Apr 2010 14:38
Last Modified: 27 Mar 2014 19:05

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