Surgical resection versus radiofrequency ablation in the treatment of small unifocal hepatocellular carcinoma

Abu-Hilal, M., Primrose, J.N., Casaril, A., McPhail, M.J.W., Pearce, N.W. and Nicoli, N. (2008) Surgical resection versus radiofrequency ablation in the treatment of small unifocal hepatocellular carcinoma. Journal of Gastrointestinal Surgery, 12, (9), 1521-1526. (doi:10.1007/s11605-008-0553-4).


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Background: hepatocellular carcinoma (HCC) has a high worldwide prevalence and mortality. While surgical resection and transplantation offers curative potential, donor availability and patient liver status and comorbidities may disallow either. Interventional radiological techniques such as radiofrequency ablation (RFA) may offer acceptable overall and disease-free survival rates.

Materials and Methods: sixty-eight cirrhotic patients matched for age, sex, tumor size, and Child–Pugh grade with small (1–5 cm) unifocal HCC were studied retrospectively to find determinants of overall and disease-free survival in those treated with surgical resection and RFA between 1991 and 2003.
Results Multivariate analysis using Cox proportional regression modeling showed that overall survival was related to tumor recurrence (p?=?0.010), tumor diameter (p?=?0.002), and treatment modality (p?=?0.014); overall p?=?0.008. Recurrence was independently related to the use of RFA over surgery (p?=?0.023) on multivariate analysis; overall p?=?0.034.

Conclusion: surgical resection offers longer disease-free survival and potentially longer overall survival than RFA in patients with small unifocal HCC.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/s11605-008-0553-4
ISSNs: 1091-255X (print)
1873-4626 (electronic)
Related URLs:
Keywords: hepatocellular carcinoma, radio frequency ablation, resection
Subjects: R Medicine > RD Surgery
Divisions : University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
ePrint ID: 144851
Accepted Date and Publication Date:
September 2008Published
Date Deposited: 15 Apr 2010 10:27
Last Modified: 31 Mar 2016 13:20

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