Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes
Davis, Jeffery T., Gale, Philip A., Okunola, Oluyomi A., Prados, Pilar, Iglesias-Sánchez, Jose Carlos, Torroba, Tomás and Quesada, Roberto (2009) Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes. Nature Chemistry, 1, (2), 138-144. (doi:10.1038/nchem.178).
Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the natural product prodigiosin, a tripyrrolic molecule produced by microorganisms such as Streptomyces and Serratia, facilitates chloride/bicarbonate exchange (antiport) across liposomal membranes. Higher concentrations of simple synthetic molecules based on a 4,6-dihydroxyisophthalamide core are also shown to facilitate this antiport process. Although it is well known that proteins regulate Cl-/HCO3- exchange in cells, these results suggest that small molecules may also be able to regulate the concentration of these anions in biological systems.
|Subjects:||Q Science > QD Chemistry|
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||15 Apr 2010 13:08|
|Last Modified:||19 Apr 2013 14:37|
|Contributors:||Davis, Jeffery T. (Author)
Gale, Philip A. (Author)
Okunola, Oluyomi A. (Author)
Prados, Pilar (Author)
Iglesias-Sánchez, Jose Carlos (Author)
Torroba, Tomás (Author)
Quesada, Roberto (Author)
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
Actions (login required)