Chapter 9 Polyunsaturated fatty acids, brain phospholipids and the fetal alcohol syndrome
Burdge, Graham C. and Postle, Anthony D. (2002) Chapter 9 Polyunsaturated fatty acids, brain phospholipids and the fetal alcohol syndrome. In, Krebs, Joachim and Michalak, Marek (eds.) Brain Lipids and Disorders in Biological Psychiatry. Kidlington, GB, Elsevier , 159-167. (New Comprehensive Biochemistry, 35). (doi:10.1016/S0167-7306(02)35038-5).
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Although to date these observations in the fetal guinea pig have not been substantiated in humans, they provide strong preliminary evidence that impaired accumulation of DHA into brain phospholipids may be one important mechanism in the pathogenesis of FAS. Furthermore, since increasing DHA availability to the mother, and presumably the fetus, appeared to produce a reduction in the severity of ethanol-induced neurological damage it is possible that maternal DHA supplementation may provide a therapeutic strategy in humans FAS. Alternatively, the prolonged period of postnatal brain development in the human may permit appropriate dietary DHA supplementation of the affected infants after delivery, which would potentially be a more practical clinical intervention.
|Item Type:||Book Section|
|Digital Object Identifier (DOI):||doi:10.1016/S0167-7306(02)35038-5|
|Subjects:||H Social Sciences > HQ The family. Marriage. Woman
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||07 Jul 2010 15:24|
|Last Modified:||06 Aug 2015 03:00|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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