mTOR’s role in ageing: protein synthesis or autophagy?
mTOR’s role in ageing: protein synthesis or autophagy?
The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.
ageing, TOR, protein synthesis, autophagy, rapamycin
586-597
Hands, Sarah L.
a4b27f4b-9af4-4513-87ae-69004135e119
Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3
Wyttenbach, Andreas
05019897-52b1-4bb6-b259-5d51abae7540
20 July 2009
Hands, Sarah L.
a4b27f4b-9af4-4513-87ae-69004135e119
Proud, Christopher G.
59dabfc8-4b44-4be8-a17f-578a58550cb3
Wyttenbach, Andreas
05019897-52b1-4bb6-b259-5d51abae7540
Hands, Sarah L., Proud, Christopher G. and Wyttenbach, Andreas
(2009)
mTOR’s role in ageing: protein synthesis or autophagy?
Aging, 1 (7), .
Abstract
The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.
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Published date: 20 July 2009
Keywords:
ageing, TOR, protein synthesis, autophagy, rapamycin
Identifiers
Local EPrints ID: 145339
URI: http://eprints.soton.ac.uk/id/eprint/145339
ISSN: 1945-4589
PURE UUID: 7e76dd32-07c3-4238-bf4a-b3db92b231d1
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Date deposited: 19 Apr 2010 11:00
Last modified: 14 Mar 2024 00:50
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Contributors
Author:
Sarah L. Hands
Author:
Christopher G. Proud
Author:
Andreas Wyttenbach
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