Heat shock proteins: therapeutic drug targets for chronic neurodegeneration?
Sajjad, M. U., Samson, B. and Wyttenbach, A. (2010) Heat shock proteins: therapeutic drug targets for chronic neurodegeneration? Current Pharmaceutical Biotechnology, 11, (2), 198-215. (doi:10.2174/138920110790909641).
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Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases (“proteinopathies”). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimer's- and Parkinson's disease, the polyglutamine- and prion disorders and Amyotrophic Lateral Sclerosis.
|Digital Object Identifier (DOI):||doi:10.2174/138920110790909641|
|Divisions :||University Structure - Pre August 2011 > School of Biological Sciences
|Accepted Date and Publication Date:||
|Date Deposited:||19 Apr 2010 08:30|
|Last Modified:||31 Mar 2016 13:20|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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