From pharmacokinetics to therapeutics
From pharmacokinetics to therapeutics
Whilst pharmacokinetics describe the relationship between dose levels and concentration-time profiles of a drug in the body and pharmacodynamics describe the concentration-response relationships, pharmacokinectics-pharmacodynamics(PK-PD) models link these two items providing a framework for modelling the time course of drug response. In this chapter, PK-PD models, describing the therapeutic effects of drugs used for the therapy of allergic diseases have been reviewed. Emphasis was given also to the description of the receptor occupancy, which is tightly related to the downstream clinical response. PK - PD models describing unwanted effects were also commented. An integrated use of these models allows choosing appropriate dosing regimens and providing an objective evaluation of the benefit/risk balance
455-474
Church, Martin K.
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Gillard, Michel
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Sargentini-Maier, Maria Laura
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Poggesi, Italo
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Campbell, Alison
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Strolin-Benedetti, Margherita
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August 2009
Church, Martin K.
dad189d5-866e-4ae1-b005-0d87f74282b8
Gillard, Michel
56bd2536-a08e-4c40-b0cf-7242d1826fb3
Sargentini-Maier, Maria Laura
045d3402-27a0-480c-a0be-9fc5a0496689
Poggesi, Italo
f6519e3f-f0e1-47d6-a78c-2b2bcdb0a823
Campbell, Alison
1c50d4af-ab60-4608-8491-381021e3beba
Strolin-Benedetti, Margherita
817d5b13-c45e-4955-91ee-86a2a9835a25
Church, Martin K., Gillard, Michel, Sargentini-Maier, Maria Laura, Poggesi, Italo, Campbell, Alison and Strolin-Benedetti, Margherita
(2009)
From pharmacokinetics to therapeutics.
Drug Metabolism Reviews, 41 (3), .
(doi:10.1080/10837450902891535).
Abstract
Whilst pharmacokinetics describe the relationship between dose levels and concentration-time profiles of a drug in the body and pharmacodynamics describe the concentration-response relationships, pharmacokinectics-pharmacodynamics(PK-PD) models link these two items providing a framework for modelling the time course of drug response. In this chapter, PK-PD models, describing the therapeutic effects of drugs used for the therapy of allergic diseases have been reviewed. Emphasis was given also to the description of the receptor occupancy, which is tightly related to the downstream clinical response. PK - PD models describing unwanted effects were also commented. An integrated use of these models allows choosing appropriate dosing regimens and providing an objective evaluation of the benefit/risk balance
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Published date: August 2009
Identifiers
Local EPrints ID: 145641
URI: http://eprints.soton.ac.uk/id/eprint/145641
ISSN: 0360-2532
PURE UUID: dcd57e0c-91a2-4634-a746-b53642ba5081
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Date deposited: 19 Apr 2010 13:04
Last modified: 14 Mar 2024 00:51
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Contributors
Author:
Martin K. Church
Author:
Michel Gillard
Author:
Maria Laura Sargentini-Maier
Author:
Italo Poggesi
Author:
Alison Campbell
Author:
Margherita Strolin-Benedetti
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