The University of Southampton
University of Southampton Institutional Repository

Cancer Pain: Part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners

Cancer Pain: Part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners
Cancer Pain: Part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners
Objective. This discussion document about the management of cancer pain is written from the pain specialists' perspective in order to provoke thought and interest in a multimodal approach to the management of cancer pain, not just towards the end of life, but pain at diagnosis, as a consequence of cancer therapies, and in cancer survivors. It relates the science of pain to the clinical setting and explains the role of psychological, physical, interventional and complementary therapies in cancer pain.

Methods. This document has been produced by a consensus group of relevant health care professionals in the United Kingdom and patients' representatives making reference to the current body of evidence relating to cancer pain. In the first of two parts, pathophysiology, oncological, pharmacological, and psychological treatment are considered.

Conclusions. It is recognized that the World Health Organization (WHO) analgesic ladder, while providing relief of cancer pain towards the end of life for many sufferers worldwide, may have limitations in the context of longer survival and increasing disease complexity. To complement this, it is suggested that a more comprehensive model of managing cancer pain is needed that is mechanism-based and multimodal, using combination therapies including interventions where appropriate, tailored to the needs of an individual, with the aim to optimize pain relief with minimization of adverse effects.
palliative care, pain, neoplasms, therapeutics
1526-2375
742-764
Raphael, Jon
fbf9f519-489a-4e99-86e9-a5aff476b1e8
Hester, Joan
743cabc0-2860-4d58-83aa-612d9045a869
Ahmedzai, Sam
4a6321f1-7ef0-430e-a7f6-a1b70b038599
Barrie, Janette
fd73d87f-50c5-470b-b918-18a81576ecf7
Farqhuar-Smith, Paul
b7aafd29-c418-474b-9d05-5861f405a29b
Williams, John
52748571-88b8-4ca1-8b35-b33f9b8a429f
Urch, Catherine
0a26dbce-ef05-45e5-bce2-c4599f18d05b
Bennett, Michael
b5976b37-b115-4044-9baa-df409c391b17
Robb, Karen
cfccf72d-97ac-4797-8d1d-225869486f84
Simpson, Brian
21999eac-5dd8-49f6-85e5-d68aff37cc0f
Pittler, Max
43571c3c-d572-4025-a8b0-eab724e53cac
Wider, Barbara
b3298350-21b5-4733-8891-7570a59bf789
Ewer-Smith, Charlie
afc88cb8-cdf1-427d-a321-bacfc4455b00
DeCourcy, James
262b4afc-3286-4197-ae32-85d843afcc85
Young, Ann
9e4bcc2f-8b75-4bdc-8c72-2a61fb216d46
Liossi, Christina
fd401ad6-581a-4a31-a60b-f8671ffd3558
McCullough, Renee
5d409cc0-431e-430e-bc43-00183a143d7f
Rajapakse, Dilini
27d8a931-1725-429c-b1d3-4d62d66deefd
Johnson, Martin
4f367e84-7adf-4d70-a6a9-afc78017ad12
Duarte, Rui
44888662-fe7a-4843-8b51-7b1d75d1ddfa
Sparkes, Elizabeth
81e621da-30ba-4dce-9c35-b1a873bd9a9b
Raphael, Jon
fbf9f519-489a-4e99-86e9-a5aff476b1e8
Hester, Joan
743cabc0-2860-4d58-83aa-612d9045a869
Ahmedzai, Sam
4a6321f1-7ef0-430e-a7f6-a1b70b038599
Barrie, Janette
fd73d87f-50c5-470b-b918-18a81576ecf7
Farqhuar-Smith, Paul
b7aafd29-c418-474b-9d05-5861f405a29b
Williams, John
52748571-88b8-4ca1-8b35-b33f9b8a429f
Urch, Catherine
0a26dbce-ef05-45e5-bce2-c4599f18d05b
Bennett, Michael
b5976b37-b115-4044-9baa-df409c391b17
Robb, Karen
cfccf72d-97ac-4797-8d1d-225869486f84
Simpson, Brian
21999eac-5dd8-49f6-85e5-d68aff37cc0f
Pittler, Max
43571c3c-d572-4025-a8b0-eab724e53cac
Wider, Barbara
b3298350-21b5-4733-8891-7570a59bf789
Ewer-Smith, Charlie
afc88cb8-cdf1-427d-a321-bacfc4455b00
DeCourcy, James
262b4afc-3286-4197-ae32-85d843afcc85
Young, Ann
9e4bcc2f-8b75-4bdc-8c72-2a61fb216d46
Liossi, Christina
fd401ad6-581a-4a31-a60b-f8671ffd3558
McCullough, Renee
5d409cc0-431e-430e-bc43-00183a143d7f
Rajapakse, Dilini
27d8a931-1725-429c-b1d3-4d62d66deefd
Johnson, Martin
4f367e84-7adf-4d70-a6a9-afc78017ad12
Duarte, Rui
44888662-fe7a-4843-8b51-7b1d75d1ddfa
Sparkes, Elizabeth
81e621da-30ba-4dce-9c35-b1a873bd9a9b

Raphael, Jon, Hester, Joan, Ahmedzai, Sam, Barrie, Janette, Farqhuar-Smith, Paul, Williams, John, Urch, Catherine, Bennett, Michael, Robb, Karen, Simpson, Brian, Pittler, Max, Wider, Barbara, Ewer-Smith, Charlie, DeCourcy, James, Young, Ann, Liossi, Christina, McCullough, Renee, Rajapakse, Dilini, Johnson, Martin, Duarte, Rui and Sparkes, Elizabeth (2010) Cancer Pain: Part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners. Pain Medicine, 11 (5), 742-764. (doi:10.1111/j.1526-4637.2010.00840.x). (PMID:20546514)

Record type: Article

Abstract

Objective. This discussion document about the management of cancer pain is written from the pain specialists' perspective in order to provoke thought and interest in a multimodal approach to the management of cancer pain, not just towards the end of life, but pain at diagnosis, as a consequence of cancer therapies, and in cancer survivors. It relates the science of pain to the clinical setting and explains the role of psychological, physical, interventional and complementary therapies in cancer pain.

Methods. This document has been produced by a consensus group of relevant health care professionals in the United Kingdom and patients' representatives making reference to the current body of evidence relating to cancer pain. In the first of two parts, pathophysiology, oncological, pharmacological, and psychological treatment are considered.

Conclusions. It is recognized that the World Health Organization (WHO) analgesic ladder, while providing relief of cancer pain towards the end of life for many sufferers worldwide, may have limitations in the context of longer survival and increasing disease complexity. To complement this, it is suggested that a more comprehensive model of managing cancer pain is needed that is mechanism-based and multimodal, using combination therapies including interventions where appropriate, tailored to the needs of an individual, with the aim to optimize pain relief with minimization of adverse effects.

Text
Pain_Medicine_paper.pdf - Other
Restricted to Registered users only
Download (517kB)
Request a copy

More information

Submitted date: 8 January 2010
e-pub ahead of print date: 23 April 2010
Published date: May 2010
Keywords: palliative care, pain, neoplasms, therapeutics

Identifiers

Local EPrints ID: 146299
URI: http://eprints.soton.ac.uk/id/eprint/146299
ISSN: 1526-2375
PURE UUID: a8f135f7-dbbc-4ee6-b361-65d41f29e5c3
ORCID for Christina Liossi: ORCID iD orcid.org/0000-0003-0627-6377

Catalogue record

Date deposited: 23 Apr 2010 09:41
Last modified: 14 Mar 2024 02:51

Export record

Altmetrics

Contributors

Author: Jon Raphael
Author: Joan Hester
Author: Sam Ahmedzai
Author: Janette Barrie
Author: Paul Farqhuar-Smith
Author: John Williams
Author: Catherine Urch
Author: Michael Bennett
Author: Karen Robb
Author: Brian Simpson
Author: Max Pittler
Author: Barbara Wider
Author: Charlie Ewer-Smith
Author: James DeCourcy
Author: Ann Young
Author: Renee McCullough
Author: Dilini Rajapakse
Author: Martin Johnson
Author: Rui Duarte
Author: Elizabeth Sparkes

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×