From proteomics to prescription - the search for COPD biomarkers
From proteomics to prescription - the search for COPD biomarkers
Biomarkers that describe the severity and progression of COPD and the responses of patients to treatment are a desirable addition to clinical measures of disease. In this review, we describe the current state of knowledge of biomarkers used for the diagnosis, staging and therapeutic response of COPD patients. The nature of these biomarkers is considered in relation to their intended use, and the desirable qualities of such entities are examined. Examples of biased and unbiased discovery platforms for COPD biomarker discovery are given, and the major findings of these studies are discussed. Cutting edge technology used for biomarker discovery, quantitation in biofluids and imaging biomarkers in whole body systems is reviewed.
proteomics, chronic obstructive pulmonary disease, biomarkers, mass spectrometry, bodily secretions, diagnosis
298-303
Nicholas, Benjamin L
785c44fb-6536-4189-803b-4545425e9385
O'Connor, David
7c29ec66-081e-46f0-8be8-bac6a7dc8de8
Djukanovic, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
August 2009
Nicholas, Benjamin L
785c44fb-6536-4189-803b-4545425e9385
O'Connor, David
7c29ec66-081e-46f0-8be8-bac6a7dc8de8
Djukanovic, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Nicholas, Benjamin L, O'Connor, David and Djukanovic, Ratko
(2009)
From proteomics to prescription - the search for COPD biomarkers.
COPD: Journal of Chronic Obstructive Pulmonary Disease, 6 (4), .
(doi:10.1080/15412550903049140).
Abstract
Biomarkers that describe the severity and progression of COPD and the responses of patients to treatment are a desirable addition to clinical measures of disease. In this review, we describe the current state of knowledge of biomarkers used for the diagnosis, staging and therapeutic response of COPD patients. The nature of these biomarkers is considered in relation to their intended use, and the desirable qualities of such entities are examined. Examples of biased and unbiased discovery platforms for COPD biomarker discovery are given, and the major findings of these studies are discussed. Cutting edge technology used for biomarker discovery, quantitation in biofluids and imaging biomarkers in whole body systems is reviewed.
This record has no associated files available for download.
More information
Published date: August 2009
Keywords:
proteomics, chronic obstructive pulmonary disease, biomarkers, mass spectrometry, bodily secretions, diagnosis
Identifiers
Local EPrints ID: 146345
URI: http://eprints.soton.ac.uk/id/eprint/146345
ISSN: 1541-2555
PURE UUID: a66ff7a6-76f7-4d12-923b-c99f6033693c
Catalogue record
Date deposited: 22 Apr 2010 10:32
Last modified: 14 Mar 2024 02:48
Export record
Altmetrics
Contributors
Author:
Benjamin L Nicholas
Author:
David O'Connor
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics