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Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable?

Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable?
Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable?
Background
Exhaled nitric oxide is a non-invasive marker of airway inflammation and a portable analyser, the NIOX MINO (Aerocrine AB, Solna, Sweden), is now available. This study aimed to assess the reproducibility of the NIOX MINO measurements across age, sex and lung function for both absolute and categorical exhaled nitric oxide values in two distinct groups of children and teenagers.

Methods
Paired exhaled nitric oxide readings were obtained from 494 teenagers, aged 16-18 years, enrolled in an unselected birth cohort and 65 young people, aged 6-17 years, with asthma enrolled in an interventional asthma management study.

Results
The birth cohort participants showed a high degree of variability between first and second exhaled nitric oxide readings (mean intra-participant difference 1.37 ppb, 95% limits of agreement -7.61 to 10.34 ppb), although there was very close agreement when values were categorised as low, normal, intermediate or high (kappa = 0.907, p < 0.001). Similar findings were seen in subgroup analyses by sex, lung function and asthma status. Similar findings were seen in the interventional study participants.

Conclusions
The reproducibility of exhaled nitric oxide is poor for absolute values but acceptable when values are categorised as low, normal, intermediate or high in children and teenagers. One measurement is therefore sufficient when using categorical exhaled nitric oxide values to direct asthma management but a mean of at least two measurements is required for absolute values.
1465-9921
Selby, Anna
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Claton, Bernie
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Grundy, Jane
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Pike, Katy
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Drew, Kirsty
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Raza, Abid
0bcd5946-167e-4e75-9eaf-906e980ee498
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Selby, Anna
69fd5ea1-f24a-4a04-ad88-3c0fb947aa88
Claton, Bernie
91c43678-95c0-4de1-8ddd-65ee1bc10237
Grundy, Jane
f8d6ced1-b9ab-4ee9-aa14-2f2805597fbe
Pike, Katy
10be90c8-73de-416e-a2d0-0bb7e7276bd3
Drew, Kirsty
2d27352c-9c49-497e-ab06-cb9695c8eaf3
Raza, Abid
0bcd5946-167e-4e75-9eaf-906e980ee498
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3

Selby, Anna, Claton, Bernie, Grundy, Jane, Pike, Katy, Drew, Kirsty, Raza, Abid, Kurukulaaratchy, Ramesh, Arshad, S. Hasan and Roberts, Graham (2010) Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable? Respiratory Research, 11 (43). (doi:10.1186/1465-9921-11-43). (PMID:20416092)

Record type: Article

Abstract

Background
Exhaled nitric oxide is a non-invasive marker of airway inflammation and a portable analyser, the NIOX MINO (Aerocrine AB, Solna, Sweden), is now available. This study aimed to assess the reproducibility of the NIOX MINO measurements across age, sex and lung function for both absolute and categorical exhaled nitric oxide values in two distinct groups of children and teenagers.

Methods
Paired exhaled nitric oxide readings were obtained from 494 teenagers, aged 16-18 years, enrolled in an unselected birth cohort and 65 young people, aged 6-17 years, with asthma enrolled in an interventional asthma management study.

Results
The birth cohort participants showed a high degree of variability between first and second exhaled nitric oxide readings (mean intra-participant difference 1.37 ppb, 95% limits of agreement -7.61 to 10.34 ppb), although there was very close agreement when values were categorised as low, normal, intermediate or high (kappa = 0.907, p < 0.001). Similar findings were seen in subgroup analyses by sex, lung function and asthma status. Similar findings were seen in the interventional study participants.

Conclusions
The reproducibility of exhaled nitric oxide is poor for absolute values but acceptable when values are categorised as low, normal, intermediate or high in children and teenagers. One measurement is therefore sufficient when using categorical exhaled nitric oxide values to direct asthma management but a mean of at least two measurements is required for absolute values.

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More information

Published date: 23 April 2010

Identifiers

Local EPrints ID: 146369
URI: http://eprints.soton.ac.uk/id/eprint/146369
ISSN: 1465-9921
PURE UUID: 681e49e0-e31b-4c7e-8ded-16c039835a1d
ORCID for Ramesh Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 21 Apr 2010 15:57
Last modified: 14 Mar 2024 02:50

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Contributors

Author: Anna Selby
Author: Bernie Claton
Author: Jane Grundy
Author: Katy Pike
Author: Kirsty Drew
Author: Abid Raza
Author: S. Hasan Arshad
Author: Graham Roberts ORCID iD

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