Superiority of escitalopram to paroxetine in the treatment of depression


Kasper, Siegfried, Baldwin, David S., Lönn, Sara Larsson and Boulenger, Jean-Philippe (2009) Superiority of escitalopram to paroxetine in the treatment of depression. European Neuropsychopharmacology, 19, (4), 229-237. (doi:10.1016/j.euroneuro.2008.12.003 ).

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Description/Abstract

Post-hoc pooled analysis of data from two 6-month randomised controlled trials in patients with major depressive disorder (MDD) revealed superior efficacy and tolerability of escitalopram when compared with paroxetine. Escitalopram (n = 394) produced a significantly (p < 0.01) greater mean treatment difference of 2.0 points in primary endpoints, judged using the Montgomery–Åsberg Depression Rating Scale (MADRS) total score, compared with paroxetine (n = 383). Significant differences were also observed in Clinical Global Impression (CGI) — severity (escitalopram, 2.1; paroxetine, 2.4; p < 0.01) and CGI — improvement (escitalopram, 1.8; paroxetine, 2.0: p < 0.01). In the sub-group of severely depressed patients (baseline MADRS ≥ 30), escitalopram showed further improved efficacy compared with paroxetine in all scores. This analysis supports previous observations of superior efficacy and tolerability of long-term escitalopram treatment (10 to 20 mg/day) compared with paroxetine (20 to 40 mg/day). Escitalopram is a good therapeutic option for the long-term treatment of MDD, particularly in severely depressed patients.

Item Type: Article
ISSNs: 0924-977X (print)
Related URLs:
Keywords: escitalopram, major depressive disorder (MDD), selective serotonin reuptake inhibitors (SSRIs), severe depression, paroxetine
Subjects: R Medicine > R Medicine (General)
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
University Structure - Pre August 2011 > School of Medicine
ePrint ID: 148035
Date Deposited: 27 Apr 2010 09:39
Last Modified: 27 Mar 2014 19:08
URI: http://eprints.soton.ac.uk/id/eprint/148035

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