Agomelatine improves symptoms of generalised anxiety disorder
Baldwin, David S. and Lopes, Antonio T. (2009) Agomelatine improves symptoms of generalised anxiety disorder. Evidence-Based Mental Health, 12, (2), 54-54. (doi:10.1136/ebmh.12.2.54 ).
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Description/Abstract
Question:
Is agomelatine effective for people with generalised anxiety disorder?
Patients:
121 people, aged 18–65 years, with DSM-IV generalised anxiety disorder (69% female, mean age 42 years) (see online notes for exclusion criteria).
Setting:
Five centres in Finland and six centres in South Africa; time period not stated.
Intervention:
Agomelatine (n = 63; 25–50 mg/day) or placebo (n = 58) for 12 weeks. Agomelatine dose was increased from 25 to 50 mg/day if there was an insufficient response after 2 weeks. This was done in a blinded fashion, using a dose adjustment algorithm.
Outcomes:
Primary outcome: overall anxiety (HAM-A). Secondary outcomes: response (≥50% reduction in HAM-A score); somatic anxiety, psychic anxiety, severity of illness, sleep and disability symptoms (HAM-A subscales, Clinical Global Impressions Scale, Leeds Sleep Evaluation Questionnaire and Sheehan Disability Scale); discontinuation effects in the week after discontinuation (Discontinuation Emergent Signs and Symptoms scale (DESS)).
| Item Type: | Article |
|---|---|
| ISSNs: | 1362-0347 (print) 1468-960X (electronic) 1885-1177 |
| Related URLs: | |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences University Structure - Pre August 2011 > School of Medicine |
| Item ID: | 148101 |
| Date Deposited: | 27 Apr 2010 11:00 |
| Last Modified: | 02 Mar 2012 11:53 |
| Contributors: | Baldwin, David S. (Author) Lopes, Antonio T. (Author) |
| Date: | 2009 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/148101 |
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