The University of Southampton
University of Southampton Institutional Repository

Synthesis and in vitro evaluation of ?-GalCer epimers

Synthesis and in vitro evaluation of ?-GalCer epimers
Synthesis and in vitro evaluation of ?-GalCer epimers
?-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cytokines, which are released after ?-GalCer presentation, antagonize each other's effects, ?-GalCer analogues that induce a biased Th1/Th2 response are highly awaited. In this context, we report the synthesis and in vitro evaluation of ?-Gal-D-xylo-Cer and two ?-Gal-L-lyxo-Cer analogues, one with the natural acyl chain, the other with a truncated chain.
?-galactosylceramide, cytokines, epimers, glycolipids, NKT cells
1860-7179
1061-1070
Trappeniers, Matthias
003338a8-2d89-453c-86ee-67c7464e1ac3
Goormans, Stijn
b51ab85e-b3cc-4ae3-b02d-322d15400b86
Van Beneden, Katrien
d8fc2c97-163b-4422-a513-34a08745a00c
Decruy, Tine
0d799625-7310-423a-b7a7-6ece86b8ea1a
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Al-Shamkhani, Aymen
0a40b3ce-9d71-4d41-9369-7212f0a84504
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Werner, Joern M.
fba7b358-19b5-437f-bf17-47250953b1d9
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6
Trappeniers, Matthias
003338a8-2d89-453c-86ee-67c7464e1ac3
Goormans, Stijn
b51ab85e-b3cc-4ae3-b02d-322d15400b86
Van Beneden, Katrien
d8fc2c97-163b-4422-a513-34a08745a00c
Decruy, Tine
0d799625-7310-423a-b7a7-6ece86b8ea1a
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Al-Shamkhani, Aymen
0a40b3ce-9d71-4d41-9369-7212f0a84504
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Werner, Joern M.
fba7b358-19b5-437f-bf17-47250953b1d9
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6

Trappeniers, Matthias, Goormans, Stijn, Van Beneden, Katrien, Decruy, Tine, Linclau, Bruno, Al-Shamkhani, Aymen, Elliott, Tim, Ottensmeier, Christian, Werner, Joern M., Elewaut, Dirk and Van Calenbergh, Serge (2008) Synthesis and in vitro evaluation of ?-GalCer epimers. ChemMedChem, 3 (7), 1061-1070. (doi:10.1002/cmdc.200800021).

Record type: Article

Abstract

?-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cytokines, which are released after ?-GalCer presentation, antagonize each other's effects, ?-GalCer analogues that induce a biased Th1/Th2 response are highly awaited. In this context, we report the synthesis and in vitro evaluation of ?-Gal-D-xylo-Cer and two ?-Gal-L-lyxo-Cer analogues, one with the natural acyl chain, the other with a truncated chain.

This record has no associated files available for download.

More information

Published date: 14 July 2008
Keywords: ?-galactosylceramide, cytokines, epimers, glycolipids, NKT cells

Identifiers

Local EPrints ID: 148347
URI: http://eprints.soton.ac.uk/id/eprint/148347
ISSN: 1860-7179
PURE UUID: 84182c2c-f3b4-4e7f-9659-40cda0b50548
ORCID for Bruno Linclau: ORCID iD orcid.org/0000-0001-8762-0170
ORCID for Aymen Al-Shamkhani: ORCID iD orcid.org/0000-0003-0727-4189
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222

Catalogue record

Date deposited: 27 Apr 2010 15:48
Last modified: 14 Mar 2024 02:45

Export record

Altmetrics

Contributors

Author: Matthias Trappeniers
Author: Stijn Goormans
Author: Katrien Van Beneden
Author: Tine Decruy
Author: Bruno Linclau ORCID iD
Author: Tim Elliott ORCID iD
Author: Joern M. Werner
Author: Dirk Elewaut
Author: Serge Van Calenbergh

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×