Synthesis and in vitro evaluation of α-GalCer epimers
Trappeniers, Matthias, Goormans, Stijn, Van Beneden, Katrien, Decruy, Tine, Linclau, Bruno, Al-Shamkhani, Aymen, Elliott, Tim, Ottensmeier, Christian, Werner, Joern M., Elewaut, Dirk and Van Calenbergh, Serge (2008) Synthesis and in vitro evaluation of α-GalCer epimers. ChemMedChem, 3, (7), 1061-1070. (doi:10.1002/cmdc.200800021).
Full text not available from this repository.
α-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cytokines, which are released after α-GalCer presentation, antagonize each other's effects, α-GalCer analogues that induce a biased Th1/Th2 response are highly awaited. In this context, we report the synthesis and in vitro evaluation of α-Gal-D-xylo-Cer and two α-Gal-L-lyxo-Cer analogues, one with the natural acyl chain, the other with a truncated chain.
|Keywords:||α-galactosylceramide, cytokines, epimers, glycolipids, NKT cells|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||27 Apr 2010 15:48|
|Last Modified:||02 Mar 2012 13:36|
|Contributors:||Trappeniers, Matthias (Author)
Goormans, Stijn (Author)
Van Beneden, Katrien (Author)
Decruy, Tine (Author)
Linclau, Bruno (Author)
Al-Shamkhani, Aymen (Author)
Elliott, Tim (Author)
Ottensmeier, Christian (Author)
Werner, Joern M. (Author)
Elewaut, Dirk (Author)
Van Calenbergh, Serge (Author)
|Date:||14 July 2008|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
Actions (login required)