Synthesis and in vitro evaluation of α-GalCer epimers
Trappeniers, Matthias, Goormans, Stijn, Van Beneden, Katrien, Decruy, Tine, Linclau, Bruno, Al-Shamkhani, Aymen, Elliott, Tim, Ottensmeier, Christian, Werner, Joern M., Elewaut, Dirk and Van Calenbergh, Serge (2008) Synthesis and in vitro evaluation of α-GalCer epimers. ChemMedChem, 3, (7), 1061-1070. (doi:10.1002/cmdc.200800021).
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Description/Abstract
α-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cytokines, which are released after α-GalCer presentation, antagonize each other's effects, α-GalCer analogues that induce a biased Th1/Th2 response are highly awaited. In this context, we report the synthesis and in vitro evaluation of α-Gal-D-xylo-Cer and two α-Gal-L-lyxo-Cer analogues, one with the natural acyl chain, the other with a truncated chain.
| Item Type: | Article |
|---|---|
| ISSNs: | 1860-7179 (print) 1860-7187 (electronic) |
| Related URLs: | |
| Keywords: | α-galactosylceramide, cytokines, epimers, glycolipids, NKT cells |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 148347 |
| Date Deposited: | 27 Apr 2010 15:48 |
| Last Modified: | 02 Mar 2012 13:36 |
| Contributors: | Trappeniers, Matthias (Author) Goormans, Stijn (Author) Van Beneden, Katrien (Author) Decruy, Tine (Author) Linclau, Bruno (Author) Al-Shamkhani, Aymen (Author) Elliott, Tim (Author) Ottensmeier, Christian (Author) Werner, Joern M. (Author) Elewaut, Dirk (Author) Van Calenbergh, Serge (Author) |
| Date: | 14 July 2008 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/148347 |
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