No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study


Mills, Sophie, Langley, Kate, Van den Bree, Marianne, Street, Eddy, Turic, Darko, Owen, Michael J., O'Donovan, Michael C. and Thapar, Anita (2004) No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study. BMC Psychiatry, 4, (1), 1-5. (doi:10.1186/1471-244X-4-15).

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Description/Abstract

Background: Several studies have suggested an association between the functional Val158Met
polymorphism in the Catechol-O-Methyltransferase (COMT) gene and neurocognitive performance.
Two studies showed that subjects with the low activity Met allele performed better on the
Wisconsin Card Sorting Test (WCST) and another study found an effect on processing speed and
attention.

Methods: We set out to examine the association between the Val158Met polymorphism and
performance on neurocognitive tasks including those tapping working memory, attention and
speed, impulsiveness and response inhibition in a sample of 124 children with ADHD. Task
performance for each genotypic group was compared using analysis of variance.

Results: There was no evidence of association with performance on any of the neurocognitive
tasks.

Conclusions: We conclude that Val158Met COMT genotype is not associated with neurocognitive
performance in our sample.

Item Type: Article
ISSNs: 1471-244X (electronic)
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions: University Structure - Pre August 2011 > School of Psychology > Division of Clinical Neuroscience
ePrint ID: 148433
Date Deposited: 05 Jul 2010 12:01
Last Modified: 27 Mar 2014 19:08
URI: http://eprints.soton.ac.uk/id/eprint/148433

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