Synthesis of the positron-emitting radiotracer [18F]-2-fluoro-2-deoxy-d-glucose from resin-bound perfluoroalkylsulfonates

Brown, Lynda J., Ma, Nianchun, Bouvet, Denis R., Champion, Sue, Gibson, Alex M., Hu, Yulai, Jackson, Alex, Khan, Imtiaz, Millot, Nicolas, Topley, Amy C., Wadsworth, Harry, Wynn, Duncan and Brown, Richard C.D. (2009) Synthesis of the positron-emitting radiotracer [18F]-2-fluoro-2-deoxy-d-glucose from resin-bound perfluoroalkylsulfonates. Organic & Biomolecular Chemistry, 7 (3), 564-575. (doi:10.1039/B816032e). (PMID:19156324)

Abstract

A new approach to the synthesis of 2-fluoro-2-deoxy-D-glucose (FDG, [19/18F]- 3) is described, which employs supported perfluoroalkylsulfonate precursors 33–36, where the support consists of insoluble polystyrene resin beads. Treatment of these resins with [19F]fluoride ion afforded protected FDG [19F]- 18 as the major product, and the identities of the main byproducts were determined. Acidic removal of the acetal protecting groups from [19F]- 18 was shown to produce [19F]FDG. The method has been applied to the efficient radiosynthesis of the imaging agent [18F]FDG, and was shown to produce the radiochemical tracer in good radiochemical yield (average 73%, decay corrected).

This record has no associated files available for download.

Contributors

Author: Lynda J. Brown

Author: Richard C.D. Brown

Download statistics