Session 2: other diseases: dietary management of osteoporosis throughout the life course
Session 2: other diseases: dietary management of osteoporosis throughout the life course
Osteoporosis-related fractures have a major impact on health at the individual and societal levels, through associated morbidity and increased mortality. Up to 50% of women and 20% of men at age 50 years may have a fragility fracture in their remaining lifetimes. Nutrition is important throughout the life course. Thus, adequate Ca and vitamin D intake has been shown to reduce risk of fracture in old age. Other factors such as protein and vitamin K may also be important, although the evidence here is less strong. In childhood Ca or vitamin D supplementation trials have demonstrated modest short-term increases in bone mass, but the long-term implications have not been established. Over recent years it has become apparent that maternal nutrition may have critical and far-reaching persistent consequences for offspring health. Thus, reduced maternal fat stores and low levels of circulating 25-hydroxyvitamin D in pregnancy are associated with reduced bone mass in the offspring; placental Ca transport may be key to these relationships. Wider maternal dietary patterns have also been shown to predict offspring bone mass. These data suggest that an interventional approach aimed at specific micronutrients, such as vitamin D, should be complemented by general optimisation of the mother's diet and lifestyle in order to maximise intrauterine bone mineral accrual and postnatal skeletal growth and thus reduce the burden of osteoporotic fractures in future generations.
osteoporosis, nutrition and bone health, conception to old age
25-33
Earl, Susie
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Cole, Zoe A.
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Holroyd, Christopher
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Cooper, Cyrus
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Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
January 2010
Earl, Susie
7f5975de-7226-4978-9d61-f33eb1c5785c
Cole, Zoe A.
6802e58a-59b3-4518-bb7d-6f721732cd61
Holroyd, Christopher
54c0e4c6-290f-4e5e-b966-4f316d656a02
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Earl, Susie, Cole, Zoe A., Holroyd, Christopher, Cooper, Cyrus and Harvey, Nicholas C.
(2010)
Session 2: other diseases: dietary management of osteoporosis throughout the life course.
Proceedings of the Nutrition Society, 69, .
(doi:10.1017/S0029665109991765).
Abstract
Osteoporosis-related fractures have a major impact on health at the individual and societal levels, through associated morbidity and increased mortality. Up to 50% of women and 20% of men at age 50 years may have a fragility fracture in their remaining lifetimes. Nutrition is important throughout the life course. Thus, adequate Ca and vitamin D intake has been shown to reduce risk of fracture in old age. Other factors such as protein and vitamin K may also be important, although the evidence here is less strong. In childhood Ca or vitamin D supplementation trials have demonstrated modest short-term increases in bone mass, but the long-term implications have not been established. Over recent years it has become apparent that maternal nutrition may have critical and far-reaching persistent consequences for offspring health. Thus, reduced maternal fat stores and low levels of circulating 25-hydroxyvitamin D in pregnancy are associated with reduced bone mass in the offspring; placental Ca transport may be key to these relationships. Wider maternal dietary patterns have also been shown to predict offspring bone mass. These data suggest that an interventional approach aimed at specific micronutrients, such as vitamin D, should be complemented by general optimisation of the mother's diet and lifestyle in order to maximise intrauterine bone mineral accrual and postnatal skeletal growth and thus reduce the burden of osteoporotic fractures in future generations.
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Published date: January 2010
Keywords:
osteoporosis, nutrition and bone health, conception to old age
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Local EPrints ID: 150231
URI: http://eprints.soton.ac.uk/id/eprint/150231
ISSN: 0029-6651
PURE UUID: 8c13e3a3-7e95-4ee3-8893-710565c652ed
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Date deposited: 04 May 2010 14:59
Last modified: 18 Mar 2024 02:58
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Author:
Susie Earl
Author:
Zoe A. Cole
Author:
Christopher Holroyd
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