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Does confined placental mosaicism account for adverse perinatal outcomes in IVF pregnancies?

Does confined placental mosaicism account for adverse perinatal outcomes in IVF pregnancies?
Does confined placental mosaicism account for adverse perinatal outcomes in IVF pregnancies?
Background: IVF singletons have poorer perinatal outcomes than singletons from spontaneous conceptions. This may be due to the influence of ovarian stimulation on the chromosomal constitution of the embryos which could be translated into localized chromosomal anomalies in the placenta. The aim of this study was to compare the incidence of confined placental mosaicism (CPM) in IVF/ICSI pregnancies and spontaneous conceptions.

Methods: we conducted a multi-centre retrospective analysis of karyotype results obtained by chorionic villus sampling (CVS), performed due to advanced maternal age (?36 years at 18 weeks of gestation), in the Netherlands between 1995 and 2005.

Results: from a total of 322 246 pregnancies, 20 885 CVS results were analysed: 235 in the IVF/ICSI group and 20 650 in the control group. The mean age of women in both groups was 38.4 years (mean difference –0.08, 95% CI –0.35 to 0.18). Data relating to the fetal karyotype were missing in 143 cases in the control group. When taking into account missing data, the incidence of CPM was lower in the IVF–ICSI group than in the control group, 1.3% versus 2.2% (odds ratio 0.59, 95% CI 0.19–1.85), whereas the incidence of fetal chromosomal anomalies was increased 4.3% versus 2.4% (odds ratio 1.81, 95% CI 0.95–3.42). Neither differences were statistically significant.

Conclusions: the incidence of CPM is not increased in IVF/ICSI pregnancies compared with spontaneous conceptions. CPM probably does not account for the adverse perinatal outcomes following IVF/ICSI.
IVF, CPM, perinatal outcomes, CVS, preimplantation genetic screening
1107-1112
Jacod, B.C.
8883d3df-1bcb-4158-a3cd-4f7eef62b67d
Lichtenbelt, K.D.
fe72c2a2-2fe2-4197-9d85-5d1ff72888d0
Schuring-Blom, G.H.
f1000fe1-2de8-4114-9183-6745c80989fa
Laven, J.S.E.
d8c987ca-d220-4010-8cb2-4ff67427c90d
van Opstal, D.
09916770-b73d-4883-be6c-cb80bbf0dc38
Eijkemans, M.J.C.
49ac87bc-76a5-493a-8d2b-37abfb606e62
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Jacod, B.C.
8883d3df-1bcb-4158-a3cd-4f7eef62b67d
Lichtenbelt, K.D.
fe72c2a2-2fe2-4197-9d85-5d1ff72888d0
Schuring-Blom, G.H.
f1000fe1-2de8-4114-9183-6745c80989fa
Laven, J.S.E.
d8c987ca-d220-4010-8cb2-4ff67427c90d
van Opstal, D.
09916770-b73d-4883-be6c-cb80bbf0dc38
Eijkemans, M.J.C.
49ac87bc-76a5-493a-8d2b-37abfb606e62
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e

Jacod, B.C., Lichtenbelt, K.D., Schuring-Blom, G.H., Laven, J.S.E., van Opstal, D., Eijkemans, M.J.C. and Macklon, N.S. (2008) Does confined placental mosaicism account for adverse perinatal outcomes in IVF pregnancies? Human Reproduction, 23 (5), 1107-1112. (doi:10.1093/humrep/den062).

Record type: Article

Abstract

Background: IVF singletons have poorer perinatal outcomes than singletons from spontaneous conceptions. This may be due to the influence of ovarian stimulation on the chromosomal constitution of the embryos which could be translated into localized chromosomal anomalies in the placenta. The aim of this study was to compare the incidence of confined placental mosaicism (CPM) in IVF/ICSI pregnancies and spontaneous conceptions.

Methods: we conducted a multi-centre retrospective analysis of karyotype results obtained by chorionic villus sampling (CVS), performed due to advanced maternal age (?36 years at 18 weeks of gestation), in the Netherlands between 1995 and 2005.

Results: from a total of 322 246 pregnancies, 20 885 CVS results were analysed: 235 in the IVF/ICSI group and 20 650 in the control group. The mean age of women in both groups was 38.4 years (mean difference –0.08, 95% CI –0.35 to 0.18). Data relating to the fetal karyotype were missing in 143 cases in the control group. When taking into account missing data, the incidence of CPM was lower in the IVF–ICSI group than in the control group, 1.3% versus 2.2% (odds ratio 0.59, 95% CI 0.19–1.85), whereas the incidence of fetal chromosomal anomalies was increased 4.3% versus 2.4% (odds ratio 1.81, 95% CI 0.95–3.42). Neither differences were statistically significant.

Conclusions: the incidence of CPM is not increased in IVF/ICSI pregnancies compared with spontaneous conceptions. CPM probably does not account for the adverse perinatal outcomes following IVF/ICSI.

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More information

Published date: May 2008
Keywords: IVF, CPM, perinatal outcomes, CVS, preimplantation genetic screening

Identifiers

Local EPrints ID: 150613
URI: http://eprints.soton.ac.uk/id/eprint/150613
PURE UUID: 9b9fd2bc-3e54-4d10-899d-7b2124033d57

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Date deposited: 05 May 2010 15:13
Last modified: 14 Mar 2024 01:17

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Contributors

Author: B.C. Jacod
Author: K.D. Lichtenbelt
Author: G.H. Schuring-Blom
Author: J.S.E. Laven
Author: D. van Opstal
Author: M.J.C. Eijkemans
Author: N.S. Macklon

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