Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment
Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment
Successful implantation is an absolute requirement for the reproduction of species, including humans. The process by which a foreign blastocyst is accepted by the maternal endometrium is complex and requires interplay of many systems. Implantation occurs during the putative implantation window, in which the maternal endometrium is ready to accept the blastocyst, which on the other hand, also plays a specific role. It produces cytokines and chemokines and expresses adhesion molecules and certain classes of MHC molecules. We review the most important players in implantation. Concerning the cytokines, the establishment of controlled aggression is key; an excess of pro- or anti-inflammation is detrimental to pregnancy outcome. Chemokines control the orientation of the embryo. The adhesion molecules are necessary to establish the required physical interaction between mother and blastocyst. Finally, immune cells and in particular, uterine NK and regulatory T cells are pivotal in inducing tolerance to the blastocyst. The aim of this review is to discuss mechanisms at play and their relative importance to the establishment of pregnancy.
regulatory T cells, tolerance, uterine NK cell, chemokine
4-19
van Mourik, Maaike S.M.
cf408d06-fdbf-41f1-84e8-c6e0ef5bfec1
Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Heijnen, Cobi J.
7327b3c6-a13d-4569-8a8a-f16dec3d9292
January 2009
van Mourik, Maaike S.M.
cf408d06-fdbf-41f1-84e8-c6e0ef5bfec1
Macklon, Nick S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Heijnen, Cobi J.
7327b3c6-a13d-4569-8a8a-f16dec3d9292
van Mourik, Maaike S.M., Macklon, Nick S. and Heijnen, Cobi J.
(2009)
Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment.
Journal of Leukocyte Biology, 85 (1), .
(doi:10.1189/jlb.0708395).
Abstract
Successful implantation is an absolute requirement for the reproduction of species, including humans. The process by which a foreign blastocyst is accepted by the maternal endometrium is complex and requires interplay of many systems. Implantation occurs during the putative implantation window, in which the maternal endometrium is ready to accept the blastocyst, which on the other hand, also plays a specific role. It produces cytokines and chemokines and expresses adhesion molecules and certain classes of MHC molecules. We review the most important players in implantation. Concerning the cytokines, the establishment of controlled aggression is key; an excess of pro- or anti-inflammation is detrimental to pregnancy outcome. Chemokines control the orientation of the embryo. The adhesion molecules are necessary to establish the required physical interaction between mother and blastocyst. Finally, immune cells and in particular, uterine NK and regulatory T cells are pivotal in inducing tolerance to the blastocyst. The aim of this review is to discuss mechanisms at play and their relative importance to the establishment of pregnancy.
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Published date: January 2009
Keywords:
regulatory T cells, tolerance, uterine NK cell, chemokine
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Local EPrints ID: 150715
URI: http://eprints.soton.ac.uk/id/eprint/150715
ISSN: 0741-5400
PURE UUID: b683b358-b11a-4ed9-b9eb-c7ee7ae0dac1
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Date deposited: 06 May 2010 11:04
Last modified: 14 Mar 2024 01:18
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Contributors
Author:
Maaike S.M. van Mourik
Author:
Nick S. Macklon
Author:
Cobi J. Heijnen
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