Review: In vitro models for the study of early human embryo-endometrium interactions
Review: In vitro models for the study of early human embryo-endometrium interactions
The molecular interactions at the embryo-endometrial interface during the period of blastocyst adhesion and subsequent invasion into the endometrial stroma are not fully understood. Current knowledge is primarily based on evidence from implantation studies in the mouse. The degree to which data derived from animal studies mirror human implantation is limited. The ethical and technical challenges studying implantation in the human can partly be overcome by designing in vitro models of embryo-endometrium interactions. In this review, the principal models in current use are described. Basic models using tissue explants and monolayers are distinguished from complex models using multilayer isolated cells, and embryo-endometrium coculture systems used therapeutically. Although there are limitations to current approaches, a number of research questions that could be addressed using these techniques are identified.
embryo implantation, in vitro model, coculture
811-818
Teklenburg, G.
4575b926-790e-4d72-a444-9bd8df4fdca9
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
24 September 2009
Teklenburg, G.
4575b926-790e-4d72-a444-9bd8df4fdca9
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Teklenburg, G. and Macklon, N.S.
(2009)
Review: In vitro models for the study of early human embryo-endometrium interactions.
Reproductive Sciences, 16 (9), .
(doi:10.1177/1933719109334966).
Abstract
The molecular interactions at the embryo-endometrial interface during the period of blastocyst adhesion and subsequent invasion into the endometrial stroma are not fully understood. Current knowledge is primarily based on evidence from implantation studies in the mouse. The degree to which data derived from animal studies mirror human implantation is limited. The ethical and technical challenges studying implantation in the human can partly be overcome by designing in vitro models of embryo-endometrium interactions. In this review, the principal models in current use are described. Basic models using tissue explants and monolayers are distinguished from complex models using multilayer isolated cells, and embryo-endometrium coculture systems used therapeutically. Although there are limitations to current approaches, a number of research questions that could be addressed using these techniques are identified.
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Published date: 24 September 2009
Keywords:
embryo implantation, in vitro model, coculture
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Local EPrints ID: 150745
URI: http://eprints.soton.ac.uk/id/eprint/150745
ISSN: 1933-7191
PURE UUID: b3d6a4eb-287f-4d96-9c4c-a3e90f9565b1
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Date deposited: 06 May 2010 12:01
Last modified: 14 Mar 2024 01:18
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Author:
G. Teklenburg
Author:
N.S. Macklon
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