Clinical, emotional and social factors associated with quality of life in chronic pancreatitis.


Mokrowiecka, A., Pinkowski, D., Malecka-Panas, E. and Johnson, C. D. (2010) Clinical, emotional and social factors associated with quality of life in chronic pancreatitis. Pancreatology, 10, (1), 39-46. (doi:10.1159/000225920).

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Description/Abstract

Background:

In chronic pancreatitis (CP), a debilitating, progressive and incurable disease, patients' wellbeing is considerably impaired, but the different factors affecting quality of life (QoL), have not been identified yet.

Methods:

69 patients with CP were evaluated (M/F 55/14; mean age 46.6 +/- 10.05 years). Different degrees of pancreatic damage were defined using the Cambridge classification; pain intensity and frequency were assessed using pain index. QoL was measured using EORTC QLQ-C30 and the PAN26 questionnaire. Although developed for pancreatic cancer, the C30/PAN26 has been validated for chronic pancreatitis.

Results:

Digestive symptoms, financial difficulties, fear of future health and general pain scales showed considerable effects of CP on QoL. We observed significant negative correlation between mean QoL scores and pain index in almost all domains (p < 0.001, p < 0.05). Pain intensity affects QoL scales more often than pain frequency. BMI correlated positively with QoL in global health status, altered bowel habits, body image and satisfaction with health care domains (p < 0.01, p < 0.05).

Conclusion:

Pain index, BMI, Cambridge classification and disease duration are the most important factors adversely affecting QoL in CP. Measurement of QoL is essential in the disease management and improves the knowledge of psychosocial functioning of these patients. and IAP.

Item Type: Article
ISSNs: 1424-3903 (print)
1424-3911 (electronic)
Related URLs:
Keywords: chronic pancreatitis, EORTC QLQ-C30, EORTC PAN26, quality of life
Subjects: R Medicine > RD Surgery
Divisions: University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
ePrint ID: 150879
Date Deposited: 07 May 2010 08:11
Last Modified: 27 Mar 2014 19:10
URI: http://eprints.soton.ac.uk/id/eprint/150879

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