Neisseria meningitidis sequence type and risk for death, Iceland
Neisseria meningitidis sequence type and risk for death, Iceland
Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and sequence types (STs) with outcomes. Overall, 59 different STs were identified, 19 of which were unique to Iceland. The most common STs were 32 (24.6%), 11 (19.9%), and 10 (10.2%). The unique ST-3492 ranked fourth (7.7%). The most common serogroups were B (56.4%), C (39.8%), and A (2.2%). Age (p < 0.001) and infection with a unique ST (p = 0.011) were independently associated with increased death rates, whereas isolation of meningococci from cerebrospinal fluid only was associated with lower death rates (p = 0.046). This study shows evolutionary trends of meningococcal isolates in a relatively isolated community and highlights an association between unique STs and poor outcome.
1066-1073
Gottfredsson, Magnus
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Diggle, Mathew A.
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Lawrie, David I.
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Erlendsdottir, Helga
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Hardarottir, Hjordis
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Kristinsson,, Karl G
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Clarke, Stuart C.
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July 2006
Gottfredsson, Magnus
336cac9b-5a89-439a-b2ce-f2b3a9fb4eea
Diggle, Mathew A.
d739c25b-e038-4a9a-850d-2e2fd6ff4a4f
Lawrie, David I.
cb1faba4-1a7f-41e2-84af-6e39360b3ae9
Erlendsdottir, Helga
b3ca6623-a231-41df-88ec-389949c77c67
Hardarottir, Hjordis
9454191f-cc84-4b17-919c-c52acf8b92c2
Kristinsson,, Karl G
496473b9-7f07-4bc1-9050-1c6a8ca95a14
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Gottfredsson, Magnus, Diggle, Mathew A., Lawrie, David I., Erlendsdottir, Helga, Hardarottir, Hjordis, Kristinsson,, Karl G and Clarke, Stuart C.
(2006)
Neisseria meningitidis sequence type and risk for death, Iceland.
Emerging Infectious Diseases, 12 (7), .
Abstract
Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and sequence types (STs) with outcomes. Overall, 59 different STs were identified, 19 of which were unique to Iceland. The most common STs were 32 (24.6%), 11 (19.9%), and 10 (10.2%). The unique ST-3492 ranked fourth (7.7%). The most common serogroups were B (56.4%), C (39.8%), and A (2.2%). Age (p < 0.001) and infection with a unique ST (p = 0.011) were independently associated with increased death rates, whereas isolation of meningococci from cerebrospinal fluid only was associated with lower death rates (p = 0.046). This study shows evolutionary trends of meningococcal isolates in a relatively isolated community and highlights an association between unique STs and poor outcome.
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Published date: July 2006
Identifiers
Local EPrints ID: 152843
URI: http://eprints.soton.ac.uk/id/eprint/152843
ISSN: 1080-6059
PURE UUID: 3c83f8ab-444c-4837-87eb-f8dccedfa4e5
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Date deposited: 17 Jun 2010 15:23
Last modified: 14 Mar 2024 02:51
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Contributors
Author:
Magnus Gottfredsson
Author:
Mathew A. Diggle
Author:
David I. Lawrie
Author:
Helga Erlendsdottir
Author:
Hjordis Hardarottir
Author:
Karl G Kristinsson,
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