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The deliverability, acceptability and perceived effect of the Macmillan Approach to Weight loss and Eating difficulties (MAWE): Phase II cluster randomised exploratory trial of a psychosocial intervention for weight- and eating-related distress in people with advanced cancer.

The deliverability, acceptability and perceived effect of the Macmillan Approach to Weight loss and Eating difficulties (MAWE): Phase II cluster randomised exploratory trial of a psychosocial intervention for weight- and eating-related distress in people with advanced cancer.
The deliverability, acceptability and perceived effect of the Macmillan Approach to Weight loss and Eating difficulties (MAWE): Phase II cluster randomised exploratory trial of a psychosocial intervention for weight- and eating-related distress in people with advanced cancer.
Context: Up to 80% of people with cancer will develop weight loss and anorexia during the advanced stages of the disease. The Macmillan Weight and Eating Studies (2000–2009) have used the Medical Research Council complex interventions framework to develop the first psychosocial intervention for weight- and eating-related distress (WRD and ERD) in people with advanced cancer and their carers: The Macmillan Approach to Weight and Eating (MAWE).

Objectives: This article reports the findings of a Phase II trial of MAWE that investigated its deliverability, acceptability, and patient-perceived effect on WRD and ERD.

Methods: The Phase II trial, conducted in 2006–2007, was of cluster-randomized design, with two community palliative care teams randomized to different arms. It used mixed methods to compare an intervention group (n = 25), the MAWE group, which was supported by MAWE-trained clinical nurse specialists, with a group that received usual care (n = 25), the control group.

Results: MAWE was deliverable in clinical practice and acceptable to patients. Unplanned exposure of the MAWE group to the intervention before an initial measure of WRD and ERD proved problematic to the trial process. Despite this, quantitative and qualitative analyses indicate that MAWE does not exacerbate WRD and ERD and may help patients with advanced cancer live with the weight loss and anorexia that are the symptoms of cancer cachexia syndrome.

Conclusion: A follow-on randomized controlled trial of MAWE is warranted but should be of a revised design.
phase II trial, mixed methods, cancer cachexia, weight loss, anorexia, psychosocial support, weight-related distress, eating-related distress
0885-3924
684-695
Hopkinson, J.
6cb418a6-7a9c-4b19-b84a-4c90c64339e8
Fenlon, D.
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Wright, D.N.M.
a55be721-4b15-4555-bf61-73fcb75c1a39
Okamoto, I.
fc9b4fed-0c78-4925-9e6f-2bfa7c3d48bc
Scott, I.
c958e263-8892-41b7-82db-b4f1121fc8ea
Addington-Hall, J.
87560cc4-7562-4f9b-b908-81f3b603fdd8
Foster, C.
00786ac1-bd47-4aeb-a0e2-40e058695b73
Hopkinson, J.
6cb418a6-7a9c-4b19-b84a-4c90c64339e8
Fenlon, D.
52f9a9f1-1643-449c-9856-258ef563342c
Wright, D.N.M.
a55be721-4b15-4555-bf61-73fcb75c1a39
Okamoto, I.
fc9b4fed-0c78-4925-9e6f-2bfa7c3d48bc
Scott, I.
c958e263-8892-41b7-82db-b4f1121fc8ea
Addington-Hall, J.
87560cc4-7562-4f9b-b908-81f3b603fdd8
Foster, C.
00786ac1-bd47-4aeb-a0e2-40e058695b73

Hopkinson, J., Fenlon, D., Wright, D.N.M., Okamoto, I., Scott, I., Addington-Hall, J. and Foster, C. (2010) The deliverability, acceptability and perceived effect of the Macmillan Approach to Weight loss and Eating difficulties (MAWE): Phase II cluster randomised exploratory trial of a psychosocial intervention for weight- and eating-related distress in people with advanced cancer. Journal of Pain and Symptom Management, 40 (5), 684-695. (doi:10.1016/j.jpainsymman.2010.02.015).

Record type: Article

Abstract

Context: Up to 80% of people with cancer will develop weight loss and anorexia during the advanced stages of the disease. The Macmillan Weight and Eating Studies (2000–2009) have used the Medical Research Council complex interventions framework to develop the first psychosocial intervention for weight- and eating-related distress (WRD and ERD) in people with advanced cancer and their carers: The Macmillan Approach to Weight and Eating (MAWE).

Objectives: This article reports the findings of a Phase II trial of MAWE that investigated its deliverability, acceptability, and patient-perceived effect on WRD and ERD.

Methods: The Phase II trial, conducted in 2006–2007, was of cluster-randomized design, with two community palliative care teams randomized to different arms. It used mixed methods to compare an intervention group (n = 25), the MAWE group, which was supported by MAWE-trained clinical nurse specialists, with a group that received usual care (n = 25), the control group.

Results: MAWE was deliverable in clinical practice and acceptable to patients. Unplanned exposure of the MAWE group to the intervention before an initial measure of WRD and ERD proved problematic to the trial process. Despite this, quantitative and qualitative analyses indicate that MAWE does not exacerbate WRD and ERD and may help patients with advanced cancer live with the weight loss and anorexia that are the symptoms of cancer cachexia syndrome.

Conclusion: A follow-on randomized controlled trial of MAWE is warranted but should be of a revised design.

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More information

Published date: 2010
Keywords: phase II trial, mixed methods, cancer cachexia, weight loss, anorexia, psychosocial support, weight-related distress, eating-related distress
Organisations: Faculty of Health Sciences, Health Sciences

Identifiers

Local EPrints ID: 154165
URI: http://eprints.soton.ac.uk/id/eprint/154165
ISSN: 0885-3924
PURE UUID: 455d9b94-a448-4ab2-bdf2-fec44f308714
ORCID for C. Foster: ORCID iD orcid.org/0000-0002-4703-8378

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Date deposited: 27 May 2010 13:07
Last modified: 14 Mar 2024 02:49

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Contributors

Author: J. Hopkinson
Author: D. Fenlon
Author: D.N.M. Wright
Author: I. Okamoto
Author: I. Scott
Author: C. Foster ORCID iD

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