Persistence of oxidant and protease burden in the airways after smoking cessation.
Persistence of oxidant and protease burden in the airways after smoking cessation.
Background:
Oxidative stress is associated with the pathogenesis of cigarette smoke related lung diseases, but longitudinal effects of smoking cessation on oxidant markers in the airways are unknown.
Methods:
This study included 61 smokers; 21 with chronic bronchitis or COPD, 15 asthmatics and 25 asymptomatic smokers followed up for 3 months after smoking cessation. Fractional exhaled nitric oxide (FeNO), sputum neutrophil counts, sputum 8-isoprostane, nitrotyrosine and matrix metalloproteinase-8 (MMP-8) were investigated at baseline and 1 and 3 months after smoking cessation.
Results:
After 3 months 15 subjects had succeeded in quitting of smoking and in these subjects symptoms improved significantly. Unexpectedly, however, sputum neutrophils increased (p = 0.046) after smoking cessation in patients with chronic bronchitis/COPD. At baseline, the other markers did not differ between the three groups so these results were combined for further analysis. Sputum 8-isoprostane declined significantly during the follow-up at 3 months (p = 0.035), but levels still remained significantly higher than in non-smokers. The levels of FeNO, nitrotyrosine and MMP-8 did not change significantly during the 3 months after smoking cessation.
Conclusion:
Whilst symptoms improve after smoking cessation, the oxidant and protease burden in the airways continues for months.
25
Louhelainen, Noora
a4f2a7ee-bbba-4e6a-8e07-dfecf6a0552c
Rytilä, Paula
31115afe-9e77-46f6-b737-378eb5e8d474
Haahtela, Tari
d83edd3e-f55d-41c2-93af-4d410ab935f7
Kinnula, Vuokko L.
d9e2667b-498e-44bd-9500-f76b811a29fe
Djukanović, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
27 May 2009
Louhelainen, Noora
a4f2a7ee-bbba-4e6a-8e07-dfecf6a0552c
Rytilä, Paula
31115afe-9e77-46f6-b737-378eb5e8d474
Haahtela, Tari
d83edd3e-f55d-41c2-93af-4d410ab935f7
Kinnula, Vuokko L.
d9e2667b-498e-44bd-9500-f76b811a29fe
Djukanović, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Louhelainen, Noora, Rytilä, Paula, Haahtela, Tari, Kinnula, Vuokko L. and Djukanović, Ratko
(2009)
Persistence of oxidant and protease burden in the airways after smoking cessation.
BMC Pulmonary Medicine, 9, .
(doi:10.1186/1471-2466-9-25).
Abstract
Background:
Oxidative stress is associated with the pathogenesis of cigarette smoke related lung diseases, but longitudinal effects of smoking cessation on oxidant markers in the airways are unknown.
Methods:
This study included 61 smokers; 21 with chronic bronchitis or COPD, 15 asthmatics and 25 asymptomatic smokers followed up for 3 months after smoking cessation. Fractional exhaled nitric oxide (FeNO), sputum neutrophil counts, sputum 8-isoprostane, nitrotyrosine and matrix metalloproteinase-8 (MMP-8) were investigated at baseline and 1 and 3 months after smoking cessation.
Results:
After 3 months 15 subjects had succeeded in quitting of smoking and in these subjects symptoms improved significantly. Unexpectedly, however, sputum neutrophils increased (p = 0.046) after smoking cessation in patients with chronic bronchitis/COPD. At baseline, the other markers did not differ between the three groups so these results were combined for further analysis. Sputum 8-isoprostane declined significantly during the follow-up at 3 months (p = 0.035), but levels still remained significantly higher than in non-smokers. The levels of FeNO, nitrotyrosine and MMP-8 did not change significantly during the 3 months after smoking cessation.
Conclusion:
Whilst symptoms improve after smoking cessation, the oxidant and protease burden in the airways continues for months.
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Published date: 27 May 2009
Identifiers
Local EPrints ID: 154579
URI: http://eprints.soton.ac.uk/id/eprint/154579
ISSN: 1471-2466
PURE UUID: b6e87097-b114-449b-be9b-43b84a28b185
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Date deposited: 25 May 2010 14:29
Last modified: 14 Mar 2024 02:33
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Contributors
Author:
Noora Louhelainen
Author:
Paula Rytilä
Author:
Tari Haahtela
Author:
Vuokko L. Kinnula
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