Morphological differences between beta2-microglobulin in fibrils and inclusion bodies


Taylor, Garrick F., Wood, Stephen P., Moers, Karsten, Glaubitz, Clemens, Werner, Jorn M. and Williamson, Phillip T.F. (2011) Morphological differences between beta2-microglobulin in fibrils and inclusion bodies. ChemBioChem, 12, (4), 556-558. (doi:10.1002/cbic.201000582).

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Description/Abstract

Over expression of proteins in E. coli frequently results in the production of inclusion bodies. Although β2-microglobulin frequently forms fibrillar structures, our studies reveal significant differences between the protein in fibrils and inclusion bodies. This suggests that the formation of fibrils in inclusion bodies is dependent on the propensity of the protein to form fibrillar structures.

Item Type: Article
ISSNs: 1439-4227 (print)
1439-7633 (electronic)
Keywords: amyloid fibrils, inclusion bodies, microglobulin, protein folding, solid-state nmr spectroscopy
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 154965
Date Deposited: 08 Feb 2011 09:15
Last Modified: 27 Mar 2014 19:13
URI: http://eprints.soton.ac.uk/id/eprint/154965

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