Morphological differences between beta2-microglobulin in fibrils and inclusion bodies
Taylor, Garrick F., Wood, Stephen P., Moers, Karsten, Glaubitz, Clemens, Werner, Jorn M. and Williamson, Phillip T.F. (2011) Morphological differences between beta2-microglobulin in fibrils and inclusion bodies. ChemBioChem (doi:10.1002/cbic.201000582).
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Description/Abstract
Over expression of proteins in E. coli frequently results in the production of inclusion bodies. Although β2-microglobulin frequently forms fibrillar structures, our studies reveal significant differences between the protein in fibrils and inclusion bodies. This suggests that the formation of fibrils in inclusion bodies is dependent on the propensity of the protein to form fibrillar structures.
| Item Type: | Article |
|---|---|
| ISSNs: | 1439-4227 (print) 1439-7633 (electronic) |
| Keywords: | amyloid fibrils, inclusion bodies, microglobulin, protein folding, solid-state nmr spectroscopy |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 154965 |
| Date Deposited: | 08 Feb 2011 09:15 |
| Last Modified: | 02 Mar 2012 13:37 |
| Contributors: | Taylor, Garrick F. (Author) Wood, Stephen P. (Author) Moers, Karsten (Author) Glaubitz, Clemens (Author) Werner, Jorn M. (Author) Williamson, Phillip T.F. (Author) |
| Date: | 26 January 2011 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/154965 |
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