Cloning and expression analysis of drosophila melanogaster extracellular Cu Zn SOD reveals sex specific variation


Blackney, Michael J., Shepherd, D. and Parker, J.D. (2010) Cloning and expression analysis of drosophila melanogaster extracellular Cu Zn SOD reveals sex specific variation. Journal of Insect Molecular Biology

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Description/Abstract

Abstract: The superoxide dismutase (SOD) family of enzymes regulate reactive oxygen species by scavenging superoxide. In Drosophila homologues of two of the mammalian SODs, the intracellular (Sod1) and mitochondrial (Sod2) SODs, have been studied extensively indicating a link between SOD and ageing. Recently the sequence of a third Sod gene, homologous to both mammalian (Sod3) and C. elegans (Sod4) extracellular Sod, was identified in Drosophila and is also predicted to locate extracellularly (Sod3). We have cloned and sequenced this gene, identifying two gene products formed by alternative splicing. Here we report differential sex specific Sod3 expression patterns along with validation of a Sod3 hypomorph mutant. Furthermore, we indicate a functional role of Sod3 in protecting against H2O2 induced oxidative stress.

Item Type: Article
ISSNs: 0962-1075 (print)
1365-2583 (electronic)
Related URLs:
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 154969
Date Deposited: 26 May 2010 14:03
Last Modified: 27 Mar 2014 19:13
URI: http://eprints.soton.ac.uk/id/eprint/154969

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