Can laboratory reference strains mirror "real-world" pathogenesis?

Fux, C.A., Shirtliff, M., Stoodley, P. and Costerton, J.W. (2005) Can laboratory reference strains mirror "real-world" pathogenesis? Trends in Microbiology, 13, (2), 58-63. (doi:10.1016/j.tim.2004.11.001).


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The extraordinary plasticity of bacterial genomes raises concerns about the adequacy of laboratory-adapted reference strains for the study of "real-world" pathogenesis. Some laboratory strains have been sub-cultured for decades since their first isolation and might have lost important pathophysiological characteristics. Evidence is presented that bacteria rapidly adapt to in vitro conditions. Genomic differences between laboratory reference strains and corresponding low-passage clinical isolates are reviewed. It appears that no bacterial strain can truly represent its species. For DNA microarray and proteomic studies, this limitation might be overcome by the summation of individual genomes to produce a species-specific virtual supragenome.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.tim.2004.11.001
ISSNs: 0966-842X (print)
1878-4380 (electronic)
Related URLs:
Subjects: Q Science > QR Microbiology
Divisions : University Structure - Pre August 2011 > School of Engineering Sciences > Engineering Materials & Surface Engineering
ePrint ID: 155975
Accepted Date and Publication Date:
February 2005Published
Date Deposited: 08 Jun 2010 16:13
Last Modified: 31 Mar 2016 13:26

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