Genetic loci influencing kidney function and chronic kidney disease
Chambers, John C, Zhang, Weihua, Lord, Graham M, van der Harst, Pim, Lawlor, Debbie A, Sehmi, Joban S, Gale, Daniel P, Wass, Mark N, Ahmadi, Kourosh R, Bakker, Stephan J L, Beckmann, Jacqui, Bilo, Henk J G, Bochud, Murielle, Brown, Morris J, Caulfield, Mark J, Connell, John M C, Cook, H Terence, Cotlarciuc, Ioana, Smith, George Davey, de Silva, Ranil, Deng, Guohong, Devuyst, Olivier, Roderick, Paul , Dikkeschei, Lambert D, Dimkovic, Nada and Dockrell, Mark (2010) Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42, (5), 373-375. (doi:10.1038/ng.566 ).
Download
![[img]](http://eprints.soton.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
Restricted to System admin Download (450Kb) | Request a copy |
Description/Abstract
Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease
| Item Type: | Article |
|---|---|
| ISSNs: | 1061-4036 (print) 1546-1718 (electronic) |
| Related URLs: | |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences |
| Item ID: | 156689 |
| Date Deposited: | 02 Jun 2010 13:37 |
| Last Modified: | 24 Aug 2012 00:49 |
| Contributors: | Chambers, John C (Author) Zhang, Weihua (Author) Lord, Graham M (Author) van der Harst, Pim (Author) Lawlor, Debbie A (Author) Sehmi, Joban S (Author) Gale, Daniel P (Author) Wass, Mark N (Author) Ahmadi, Kourosh R (Author) Bakker, Stephan J L (Author) Beckmann, Jacqui (Author) Bilo, Henk J G (Author) Bochud, Murielle (Author) Brown, Morris J (Author) Caulfield, Mark J (Author) Connell, John M C (Author) Cook, H Terence (Author) Cotlarciuc, Ioana (Author) Smith, George Davey (Author) de Silva, Ranil (Author) Deng, Guohong (Author) Devuyst, Olivier (Author) Roderick, Paul (Author) Dikkeschei, Lambert D (Author) Dimkovic, Nada (Author) Dockrell, Mark (Author) |
| Date: | 2010 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/156689 |
Actions (login required)
 |
View Item |
