The role of NF-kappaB in lymphoid malignancies
Packham, Graham (2008) The role of NF-kappaB in lymphoid malignancies. British Journal of Haematology, 143, (1), 3-15. (doi:10.1111/j.1365-2141.2008.07284.x).
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Nuclear Factor kappaB (NF-kappaB) transcription factors are central regulators of lymphocyte proliferation, survival and development. Although normally subject to tight control, constitutive activation of NF-kappaB promotes inappropriate lymphocyte survival and proliferation, and is recognised as key pathological feature in various lymphoid malignancies. Inhibition of NF-kappaB may be an attractive therapeutic approach in these diseases. This review focuses on the mechanisms and functional consequences of NF-kappaB activation in lymphoid malignancies and potential therapeutic strategies for inhibition of NF-kappaB.
|Keywords:||NF-κB, lymphoma, leukaemia, apoptosis, inhibitor, proteasome|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||03 Jun 2010 15:53|
|Last Modified:||02 Mar 2012 12:16|
|Contributors:||Packham, Graham (Author)
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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