The role of NF-kappaB in lymphoid malignancies
Packham, Graham (2008) The role of NF-kappaB in lymphoid malignancies. British Journal of Haematology, 143, (1), 3-15. (doi:10.1111/j.1365-2141.2008.07284.x).
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Description/Abstract
Nuclear Factor kappaB (NF-kappaB) transcription factors are central regulators of lymphocyte proliferation, survival and development. Although normally subject to tight control, constitutive activation of NF-kappaB promotes inappropriate lymphocyte survival and proliferation, and is recognised as key pathological feature in various lymphoid malignancies. Inhibition of NF-kappaB may be an attractive therapeutic approach in these diseases. This review focuses on the mechanisms and functional consequences of NF-kappaB activation in lymphoid malignancies and potential therapeutic strategies for inhibition of NF-kappaB.
| Item Type: | Article |
|---|---|
| ISSNs: | 0007-1048 (print) 1365-2141 (electronic) |
| Related URLs: | |
| Keywords: | NF-κB, lymphoma, leukaemia, apoptosis, inhibitor, proteasome |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 157107 |
| Date Deposited: | 03 Jun 2010 15:53 |
| Last Modified: | 02 Mar 2012 12:16 |
| Contributors: | Packham, Graham (Author) |
| Date: | September 2008 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/157107 |
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