Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms
Leid, Jeff G., Shirtliff, Mark E., Costerton, J. W. and Stoodley, Paul (2002) Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms. Infection and Immunity, 70, (11), 6339-6345. (doi:10.1128/IAI.70.11.6339-6345.2002).
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Staphylococcus aureus is a common pathogen responsible for nosocomial and community infections. It readily colonizes indwelling catheters, forming microbiotic communities termed biofilms. S. aureus bacteria in biofilms are protected from killing by antibiotics and the body's immune system. For years, one mechanism behind biofilm resistance to attack from the immune system's sentinel leukocytes has been conceptualized as a deficiency in the ability of the leukocytes to penetrate the biofilm. We demonstrate here that under conditions mimicking physiological shear, leukocytes attach, penetrate, and produce cytokines in response to maturing and fully matured S. aureus biofilm.
|Digital Object Identifier (DOI):||doi:10.1128/IAI.70.11.6339-6345.2002|
|Subjects:||R Medicine > R Medicine (General)
Q Science > QR Microbiology
|Divisions:||University Structure - Pre August 2011 > School of Engineering Sciences > Engineering Materials & Surface Engineering
|Date Deposited:||09 Jun 2010 14:29|
|Last Modified:||27 Mar 2014 19:14|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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