Insulin-like growth factor I and insulin and their abuse in sport
Insulin-like growth factor I and insulin and their abuse in sport
It is believed that insulin and insulin-like growth factor I (IGF-I) are abused by professional athletes, either alone or in combination with growth hormone (GH) and anabolic steroids. The recent introduction of IGF-I to clinical practice is likely to increase its availability and abuse. Insulin and IGF-I work together with GH to control the supply of nutrients to tissues in the fasted and fed state. The actions of insulin and IGF-I that may enhance performance include increased protein anabolism and glucose uptake and storage. The detection of IGF-I and insulin abuse is challenging. There are established mass spectrometry methods for insulin analogs. The feasibility of using GH-dependent markers to detect IGF-I use is being assessed.
insulin-like growth factor i, insulin, doping in sport
33-43
Erotokritou-Mulligan, Ioulietta
8bb8720a-eda7-4ad4-b969-0b35c5e5226c
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
March 2010
Erotokritou-Mulligan, Ioulietta
8bb8720a-eda7-4ad4-b969-0b35c5e5226c
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Erotokritou-Mulligan, Ioulietta and Holt, Richard I.G.
(2010)
Insulin-like growth factor I and insulin and their abuse in sport.
Endocrinology and Metabolism Clinics of North America, 39 (1), .
(doi:10.1016/j.ecl.2009.10.003).
Abstract
It is believed that insulin and insulin-like growth factor I (IGF-I) are abused by professional athletes, either alone or in combination with growth hormone (GH) and anabolic steroids. The recent introduction of IGF-I to clinical practice is likely to increase its availability and abuse. Insulin and IGF-I work together with GH to control the supply of nutrients to tissues in the fasted and fed state. The actions of insulin and IGF-I that may enhance performance include increased protein anabolism and glucose uptake and storage. The detection of IGF-I and insulin abuse is challenging. There are established mass spectrometry methods for insulin analogs. The feasibility of using GH-dependent markers to detect IGF-I use is being assessed.
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Published date: March 2010
Keywords:
insulin-like growth factor i, insulin, doping in sport
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Local EPrints ID: 157603
URI: http://eprints.soton.ac.uk/id/eprint/157603
PURE UUID: 565c05ce-4031-4d0b-8ae6-e61f0cfefb86
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Date deposited: 09 Jun 2010 08:58
Last modified: 14 Mar 2024 02:45
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Author:
Ioulietta Erotokritou-Mulligan
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