Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy
Eurelings, Marijke, Notermans, Nicolette C., Lokhorst, Henk M., van Kessel, Berris, Jacobs, Bart C., Wokke, John H.J., Sahota, Surinder S. and Bloem, Andries C. (2006) Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy. Journal of Neuroimmunology, 175, (1-2), 152-159. (doi:10.1016/j.jneuroim.2006.02.008 ).
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Antineural antibody activity is the implicated pathogenic mechanism in polyneuropathy associated with monoclonal gammopathy. Recognition of antigen depends on immunoglobulin variable regions, encoded by V genes. We studied V(H)DJ(H) and V(L)J(L) gene use in monoclonal B cells by clonal analysis in 20 patients with polyneuropathy and IgM monoclonal gammopathy. V genes associated with bacterial responses appear over-represented and V(H)3-23 was preferentially used, without association with specific D, J(H) or V(L)J(L). V genes revealed somatic mutation and intraclonal variation was found in 9 of 20 patients. Polyneuropathy associated with monoclonal gammopathy may be caused by an immune response to bacterial antigens, which recruit somatically mutated autoreactive B cells.
|Keywords:||polyneuropathy, monoclonal gammopathy, v gene analysis, anti-mag, antiganglioside|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||17 Jun 2010 14:01|
|Last Modified:||20 Jul 2012 03:32|
|Contributors:||Eurelings, Marijke (Author)
Notermans, Nicolette C. (Author)
Lokhorst, Henk M. (Author)
van Kessel, Berris (Author)
Jacobs, Bart C. (Author)
Wokke, John H.J. (Author)
Sahota, Surinder S. (Author)
Bloem, Andries C. (Author)
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