Autologous stem cell transplantation for malignancy: a systematic review of the literature
Autologous stem cell transplantation for malignancy: a systematic review of the literature
A systematic review of the literature was undertaken to assess what published evidence is currently available to support the increasing use of autologous stem cell transplantation (ASCT), and to evaluate the published data with regard to the comparative cost of high-dose and conventional therapy. The review aimed to identify all published, randomized controlled trials (RCTs) comparing high-dose therapy (HDT) with ASCT versus conventional chemotherapy (CC) in acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma, and breast, lung, testicular and ovarian cancer. The review also aimed to identify all studies that had compared the cost of the two treatment strategies. Reports were identified by systematic searches of Cancerlit, Embase and Medline, and handsearching of several conference proceedings. Where possible, pooled odds ratios (ORs) were calculated according to the fixed-effect model. A total of 18 randomized trials were identified in acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma, and breast, lung and testicular cancer. Trials were generally small and no disease site had sufficient information to determine reliably whether high-dose therapy with autologous transplant is more effective than CC. Five studies were identified that compared the cost of the two treatments. These found the cost of HDT to be between one and four times higher than that of CC. Further randomized trials are required. Where appropriate, these should include economic assessment and assessments of long-term toxicity.
61-72
Simnett, S.J.
5b6122dd-7c40-4795-849c-a1467217096c
Stewart, L. A.
3af9d04c-ec70-409f-9e5c-fd707d56d07a
Sweetenham, J.
9d52b438-479d-4613-b850-c8c7843da0a7
Morgan, G.
837bc55b-850e-4f6d-9253-e38781bf5f1e
Johnson, Peter W.M.
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
April 2000
Simnett, S.J.
5b6122dd-7c40-4795-849c-a1467217096c
Stewart, L. A.
3af9d04c-ec70-409f-9e5c-fd707d56d07a
Sweetenham, J.
9d52b438-479d-4613-b850-c8c7843da0a7
Morgan, G.
837bc55b-850e-4f6d-9253-e38781bf5f1e
Johnson, Peter W.M.
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
Simnett, S.J., Stewart, L. A., Sweetenham, J., Morgan, G. and Johnson, Peter W.M.
(2000)
Autologous stem cell transplantation for malignancy: a systematic review of the literature.
Clinical & Laboratory Haematology, 22 (2), .
Abstract
A systematic review of the literature was undertaken to assess what published evidence is currently available to support the increasing use of autologous stem cell transplantation (ASCT), and to evaluate the published data with regard to the comparative cost of high-dose and conventional therapy. The review aimed to identify all published, randomized controlled trials (RCTs) comparing high-dose therapy (HDT) with ASCT versus conventional chemotherapy (CC) in acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma, and breast, lung, testicular and ovarian cancer. The review also aimed to identify all studies that had compared the cost of the two treatment strategies. Reports were identified by systematic searches of Cancerlit, Embase and Medline, and handsearching of several conference proceedings. Where possible, pooled odds ratios (ORs) were calculated according to the fixed-effect model. A total of 18 randomized trials were identified in acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma, and breast, lung and testicular cancer. Trials were generally small and no disease site had sufficient information to determine reliably whether high-dose therapy with autologous transplant is more effective than CC. Five studies were identified that compared the cost of the two treatments. These found the cost of HDT to be between one and four times higher than that of CC. Further randomized trials are required. Where appropriate, these should include economic assessment and assessments of long-term toxicity.
Text
ASCT_systematic_review_2000.pdf
- Other
More information
Published date: April 2000
Identifiers
Local EPrints ID: 157835
URI: http://eprints.soton.ac.uk/id/eprint/157835
PURE UUID: a2691120-19a3-47f9-a533-5b080787f164
Catalogue record
Date deposited: 16 Jun 2010 13:56
Last modified: 14 Mar 2024 02:41
Export record
Contributors
Author:
S.J. Simnett
Author:
L. A. Stewart
Author:
J. Sweetenham
Author:
G. Morgan
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics