Bone tissue engineering: hope vs hype
Bone tissue engineering: hope vs hype
The requirement for new bone to replace or restore the function of traumatised, damaged, or lost bone is a major clinical and socioeconomic need. Bone formation strategies, although attractive, have yet to yield functional and mechanically competent bone. Bone tissue engineering has been heralded as the alternative strategy to regenerate bone. In essence, the discipline aims to combine progenitor or mature cells with biocompatible materials or scaffolds, with or without appropriate growth factors, to initiate repair and regeneration. This brief review outlines the concepts, challenges, and limitations in bone tissue engineering and the potential that could improve the quality of life for many as a result of interdisciplinary collaboration.
osteoprogenitor, bone marrow, biodegradable polymer, tissue engineering, scaffold, artificial bone, bone regeneration, stem cell
1-7
Rose, Felicity R.A.J.
ffeec12e-9182-4466-a719-0627b236cd22
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
2002
Rose, Felicity R.A.J.
ffeec12e-9182-4466-a719-0627b236cd22
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Rose, Felicity R.A.J. and Oreffo, Richard O.C.
(2002)
Bone tissue engineering: hope vs hype.
Biochemical and Biophysical Research Communications, 292 (1), .
(doi:10.1006/bbrc.2002.6519).
Abstract
The requirement for new bone to replace or restore the function of traumatised, damaged, or lost bone is a major clinical and socioeconomic need. Bone formation strategies, although attractive, have yet to yield functional and mechanically competent bone. Bone tissue engineering has been heralded as the alternative strategy to regenerate bone. In essence, the discipline aims to combine progenitor or mature cells with biocompatible materials or scaffolds, with or without appropriate growth factors, to initiate repair and regeneration. This brief review outlines the concepts, challenges, and limitations in bone tissue engineering and the potential that could improve the quality of life for many as a result of interdisciplinary collaboration.
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Published date: 2002
Keywords:
osteoprogenitor, bone marrow, biodegradable polymer, tissue engineering, scaffold, artificial bone, bone regeneration, stem cell
Organisations:
Dev Origins of Health & Disease
Identifiers
Local EPrints ID: 158177
URI: http://eprints.soton.ac.uk/id/eprint/158177
ISSN: 0006-291X
PURE UUID: 636dee67-9c4d-4429-b3f1-6e32c920121f
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Date deposited: 16 Jun 2010 14:12
Last modified: 14 Mar 2024 02:43
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Author:
Felicity R.A.J. Rose
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