Collectins and their role in lung immunity
Collectins and their role in lung immunity
The collectins are a small family of secreted glycoproteins that contain C-type lectin domains and collagenous regions. They have an important function in innate immunity, recognizing and binding to microorganisms via sugar arrays on the microbial surface. Their function is to enhance adhesion and phagocytosis of microorganisms by agglutination and opsonization. In the lung, two members of the collectin family, surfactant proteins A and D, are major protein constituents of surfactant. Another collectin, mannan-binding lectin, is also present in the upper airways and buccal cavity and may protect against respiratory infections. Recent work has shown that collectins have roles in resistance to allergy and in the control of apoptosis and clearance of apoptotic macrophage in the lung.
27-33
Hickling, T.P
5291adb7-436d-44a6-96d8-98e99cfda491
Clark, Howard W.
70550b6d-3bd7-47c6-8c02-4f43f37d5213
Malhotra, R.
6e6f75e3-95ad-4d65-8947-83f7b2519033
Sim, R.B.
517df90d-8f8a-43fc-b298-b0b2de719877
January 2004
Hickling, T.P
5291adb7-436d-44a6-96d8-98e99cfda491
Clark, Howard W.
70550b6d-3bd7-47c6-8c02-4f43f37d5213
Malhotra, R.
6e6f75e3-95ad-4d65-8947-83f7b2519033
Sim, R.B.
517df90d-8f8a-43fc-b298-b0b2de719877
Hickling, T.P, Clark, Howard W., Malhotra, R. and Sim, R.B.
(2004)
Collectins and their role in lung immunity.
Journal of Leukocyte Biology, 75 (1), .
(doi:10.1189/jlb.0703304).
Abstract
The collectins are a small family of secreted glycoproteins that contain C-type lectin domains and collagenous regions. They have an important function in innate immunity, recognizing and binding to microorganisms via sugar arrays on the microbial surface. Their function is to enhance adhesion and phagocytosis of microorganisms by agglutination and opsonization. In the lung, two members of the collectin family, surfactant proteins A and D, are major protein constituents of surfactant. Another collectin, mannan-binding lectin, is also present in the upper airways and buccal cavity and may protect against respiratory infections. Recent work has shown that collectins have roles in resistance to allergy and in the control of apoptosis and clearance of apoptotic macrophage in the lung.
This record has no associated files available for download.
More information
Published date: January 2004
Identifiers
Local EPrints ID: 158307
URI: http://eprints.soton.ac.uk/id/eprint/158307
ISSN: 0741-5400
PURE UUID: cd8c4b3c-d6d5-46c6-94af-434f0c3a5976
Catalogue record
Date deposited: 02 Jul 2010 13:56
Last modified: 14 Mar 2024 01:50
Export record
Altmetrics
Contributors
Author:
T.P Hickling
Author:
Howard W. Clark
Author:
R. Malhotra
Author:
R.B. Sim
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics