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Some basic relationships between density values in cancellous and cortical bone

Some basic relationships between density values in cancellous and cortical bone
Some basic relationships between density values in cancellous and cortical bone
Density is a salient property of bone and plays a crucial role in determining the mechanical properties of both its cancellous and cortical structural forms. Density is defined in a number of ways at either the bone tissue (Dapp, apparent) or the bone material level (Dmat, material). The concept of density is relatively simple, but measuring it in the context of bone is a complex issue. The third dimension of the problem is the concept of porosity, or BV/TV (ratio of bone material volume over tissue volume). Recent investigations from our laboratory have revealed an interdependence of Dapp and Dmat in the cancellous bone of at least four different cohorts of human patients. To clarify the underlying causes of this behaviour, we produced here equivalent relationships from specimens originating from cortical and cancellous areas of the same bone. Plots of Dapp vs. Dmat showed that Dmat was not a monotonic function of increasing Dapp, but instead showed a ‘boomerang’-like pattern. By empirically dissecting the data in two regions for Dapp above and below a value equal to 1.3 g cm?3, we were able to objectively isolate the bone in trabecular and compact forms. Our findings may have implications not only for the segregation of bone in these two structural forms, but also for the mechanobiological and physiological processes that govern the regulation of compact and trabecular bone areas.
bone, cancellous, cortical, density, porosity, bv/tv, mineral content
0021-9290
1961-1968
Zioupos, P.
11b6158a-2969-43b4-b19b-a01b00ee65fa
Cook, R.B.
06f8322d-81be-4f82-9326-19e55541c78f
Hutchinson, J.
b6ba9df6-2365-4a71-87dc-11807d4d10fa
Zioupos, P.
11b6158a-2969-43b4-b19b-a01b00ee65fa
Cook, R.B.
06f8322d-81be-4f82-9326-19e55541c78f
Hutchinson, J.
b6ba9df6-2365-4a71-87dc-11807d4d10fa

Zioupos, P., Cook, R.B. and Hutchinson, J. (2008) Some basic relationships between density values in cancellous and cortical bone. Journal of Biomechanics, 41 (9), 1961-1968. (doi:10.1016/j.jbiomech.2008.03.025). (PMID:18501911)

Record type: Article

Abstract

Density is a salient property of bone and plays a crucial role in determining the mechanical properties of both its cancellous and cortical structural forms. Density is defined in a number of ways at either the bone tissue (Dapp, apparent) or the bone material level (Dmat, material). The concept of density is relatively simple, but measuring it in the context of bone is a complex issue. The third dimension of the problem is the concept of porosity, or BV/TV (ratio of bone material volume over tissue volume). Recent investigations from our laboratory have revealed an interdependence of Dapp and Dmat in the cancellous bone of at least four different cohorts of human patients. To clarify the underlying causes of this behaviour, we produced here equivalent relationships from specimens originating from cortical and cancellous areas of the same bone. Plots of Dapp vs. Dmat showed that Dmat was not a monotonic function of increasing Dapp, but instead showed a ‘boomerang’-like pattern. By empirically dissecting the data in two regions for Dapp above and below a value equal to 1.3 g cm?3, we were able to objectively isolate the bone in trabecular and compact forms. Our findings may have implications not only for the segregation of bone in these two structural forms, but also for the mechanobiological and physiological processes that govern the regulation of compact and trabecular bone areas.

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More information

Published date: 2008
Keywords: bone, cancellous, cortical, density, porosity, bv/tv, mineral content
Organisations: nCATS Group

Identifiers

Local EPrints ID: 158599
URI: http://eprints.soton.ac.uk/id/eprint/158599
ISSN: 0021-9290
PURE UUID: 50233e9e-b1c5-4a9b-8fbe-82eb2a23fdb5
ORCID for R.B. Cook: ORCID iD orcid.org/0000-0002-2468-5820

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Date deposited: 26 Mar 2013 09:25
Last modified: 14 Mar 2024 02:55

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Contributors

Author: P. Zioupos
Author: R.B. Cook ORCID iD
Author: J. Hutchinson

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