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Determination of a gene and environment risk model for age-related macular degeneration

Determination of a gene and environment risk model for age-related macular degeneration
Determination of a gene and environment risk model for age-related macular degeneration
Background/aims: We have recently identified an association between age-related macular degeneration (AMD) and genetic variants in the serpin peptidase inhibitor, clade G, member 1 (SERPING1) gene. In the current study we interrogated the genomic region in linkage disequilibrium (LD) with the SERPING1 gene, and modelled the contribution to disease of known genetic and environmental AMD risk factors.

Methods: We analysed genes neighbouring SERPING1 and examined haplotype association with AMD. A stepwise logistic regression model was developed including known genetic and environmental risk factors (age, sex and smoking). Individual risk scores were assessed between groups of cases and controls.

Results: In SERPING1 region rs2511989 remains most significantly associated (p=1.77×10?5, OR 0.67). One haplotype, containing the rs2511989 variant and the majority of SERPING1, exhibits marginally stronger association (p=5.13×10?6, OR 0.66). Our risk model includes six SNPs in CFH, C3, HTRA1 and SERPING1, showing independent effects, which together account for 45% of risk of developing AMD (p=1.65×10?50) with a combined population attributable risk of 87%.

Conclusion-Results: implicate SERPING1, with no convincing evidence for involvement of other genes in the region. We demonstrate a multifactorial model with significant differences in risk scores for cases versus controls (p=9.81×10?71) and across Age-Related Eye Disease Study (AREDS) score-stratified cases (p=1.88×10?11).

0007-1161
1382-1387
Gibson, Jane
855033a6-38f3-4853-8f60-d7d4561226ae
Cree, Angela
6724b71b-8828-4abb-971f-0856c2af555e
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Gibson, Jane
855033a6-38f3-4853-8f60-d7d4561226ae
Cree, Angela
6724b71b-8828-4abb-971f-0856c2af555e
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9

Gibson, Jane, Cree, Angela, Collins, Andrew, Lotery, Andrew and Ennis, Sarah (2010) Determination of a gene and environment risk model for age-related macular degeneration. British Journal of Ophthalmology, 94 (10), 1382-1387. (doi:10.1136/bjo.2010.182568). (PMID:20576771)

Record type: Article

Abstract

Background/aims: We have recently identified an association between age-related macular degeneration (AMD) and genetic variants in the serpin peptidase inhibitor, clade G, member 1 (SERPING1) gene. In the current study we interrogated the genomic region in linkage disequilibrium (LD) with the SERPING1 gene, and modelled the contribution to disease of known genetic and environmental AMD risk factors.

Methods: We analysed genes neighbouring SERPING1 and examined haplotype association with AMD. A stepwise logistic regression model was developed including known genetic and environmental risk factors (age, sex and smoking). Individual risk scores were assessed between groups of cases and controls.

Results: In SERPING1 region rs2511989 remains most significantly associated (p=1.77×10?5, OR 0.67). One haplotype, containing the rs2511989 variant and the majority of SERPING1, exhibits marginally stronger association (p=5.13×10?6, OR 0.66). Our risk model includes six SNPs in CFH, C3, HTRA1 and SERPING1, showing independent effects, which together account for 45% of risk of developing AMD (p=1.65×10?50) with a combined population attributable risk of 87%.

Conclusion-Results: implicate SERPING1, with no convincing evidence for involvement of other genes in the region. We demonstrate a multifactorial model with significant differences in risk scores for cases versus controls (p=9.81×10?71) and across Age-Related Eye Disease Study (AREDS) score-stratified cases (p=1.88×10?11).

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Published date: June 2010

Identifiers

Local EPrints ID: 159333
URI: http://eprints.soton.ac.uk/id/eprint/159333
ISSN: 0007-1161
PURE UUID: 1452af94-3b02-42b1-92bd-35e9742c34c0
ORCID for Jane Gibson: ORCID iD orcid.org/0000-0002-0973-8285
ORCID for Angela Cree: ORCID iD orcid.org/0000-0002-1987-8900
ORCID for Andrew Collins: ORCID iD orcid.org/0000-0001-7108-0771
ORCID for Andrew Lotery: ORCID iD orcid.org/0000-0001-5541-4305
ORCID for Sarah Ennis: ORCID iD orcid.org/0000-0003-2648-0869

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Date deposited: 29 Jun 2010 14:02
Last modified: 14 Mar 2024 02:50

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