Is lifespan determined in utero?

Sayer, A.A., Cooper, C. and Barker, D.J. (1997) Is lifespan determined in utero? Archives of Diseases in Childhood Fetal Neonatal , 77, (3), F162-F164. (doi:10.1136/fn.77.3.F162).


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Low rates of growth in early life are now known to be associated with an increase in age related disease in later life.1 This is thought to reflect programming, the process whereby a stimulus or insult acting at a critical period of development in early life, has lasting or lifelong importance.2 In animal experiments that have examined the mechanisms responsible for programming, attention has focused on prenatal undernutrition and its influence on gene expression, cell division and differentiation, and tissue structure.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1136/fn.77.3.F162
ISSNs: 1468-2052 (electronic)
Related URLs:
Subjects: R Medicine > R Medicine (General)
Divisions : University Structure - Pre August 2011 > School of Medicine
ePrint ID: 159737
Accepted Date and Publication Date:
November 1997Published
Date Deposited: 07 Jul 2010 14:10
Last Modified: 31 Mar 2016 13:27

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