Microelectrode investigation of neuroneal ageing from a single identified neurone
Patel, B, Arundell, Martin, Parker, Kim H. , Yeoman , Mark S. and O'Hare, Danny (2010) Microelectrode investigation of neuroneal ageing from a single identified neurone. Physical Chemistry Chemical Physics, 12, 10065-10072. (doi:10.1039/c0cp00310g).
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Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamine neurotransmitter serotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.
|Digital Object Identifier (DOI):||doi:10.1039/c0cp00310g|
|Subjects:||Q Science > QC Physics
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Biological Sciences
|Date Deposited:||20 Jul 2010 10:28|
|Last Modified:||27 Mar 2014 19:16|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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