Taking Electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol.
Tjelle, Torunn Elisabeth, Rabussay, Dietmar, Ottensmeier, Christian, Mathiesen, Iacob and Kjeken, Rune (2008) Taking Electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol. Methods in Molecular Biology, 423, part VI, 497-507. (doi:10.1007/978-1-59745-194-9_39).
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Description/Abstract
We are presently aware of two early-phase DNA vaccine clinical trials in humans using electroporation-enhanced vaccine delivery. Moreover, two phase I immunogenetherapy studies are in progress and several tolerability studies have been performed on healthy volunteers. We have used knowledge from these studies to compose a template for clinical protocols involving electroporation-mediated gene delivery. In this template the emphasis will be on aspects related to electroporation. In addition, we will discuss general topics concerning electroporation-augmented DNA vaccination in human subjects.
| Item Type: | Article |
|---|---|
| ISSNs: | 1064-3745 (print) 1940-6029 (electronic) |
| Related URLs: | |
| Keywords: | clinical trial, electroporation, electroporation device, dna vaccination |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine Q Science > QR Microbiology > QR180 Immunology Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 160903 |
| Date Deposited: | 21 Jul 2010 10:36 |
| Last Modified: | 02 Mar 2012 12:55 |
| Contributors: | Tjelle, Torunn Elisabeth (Author) Rabussay, Dietmar (Author) Ottensmeier, Christian (Author) Mathiesen, Iacob (Author) Kjeken, Rune (Author) |
| Date: | 28 March 2008 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/160903 |
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