Taking Electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol.
Tjelle, Torunn Elisabeth, Rabussay, Dietmar, Ottensmeier, Christian, Mathiesen, Iacob and Kjeken, Rune (2008) Taking Electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol. Methods in Molecular Biology, 423, part VI, 497-507. (doi:10.1007/978-1-59745-194-9_39).
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We are presently aware of two early-phase DNA vaccine clinical trials in humans using electroporation-enhanced vaccine delivery. Moreover, two phase I immunogenetherapy studies are in progress and several tolerability studies have been performed on healthy volunteers. We have used knowledge from these studies to compose a template for clinical protocols involving electroporation-mediated gene delivery. In this template the emphasis will be on aspects related to electroporation. In addition, we will discuss general topics concerning electroporation-augmented DNA vaccination in human subjects.
|Digital Object Identifier (DOI):||doi:10.1007/978-1-59745-194-9_39|
|Keywords:||clinical trial, electroporation, electroporation device, dna vaccination|
|Subjects:||R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Q Science > QR Microbiology > QR180 Immunology
Q Science > QH Natural history > QH426 Genetics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||21 Jul 2010 10:36|
|Last Modified:||31 Mar 2016 13:28|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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