Maternal diet, behaviour and offspring skeletal health

Goodfellow, Laura R., Earl, Susannah, Cooper, Cyrus and Harvey, Nicholas C. (2010) Maternal diet, behaviour and offspring skeletal health. International Journal of Environmental Research and Public Health, 7, (4), 1760-1772. (doi:10.3390/ijerph7041760).


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Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.

Item Type: Article
Digital Object Identifier (DOI): doi:10.3390/ijerph7041760
ISSNs: 1660-4601 (print)
Related URLs:
Keywords: osteoporosis, epigenetic, early life origins, fracture, bone mass, vitamin D, neonate, fetus
Subjects: R Medicine > RB Pathology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions : University Structure - Pre August 2011 > School of Medicine
ePrint ID: 161115
Accepted Date and Publication Date:
April 2010Published
Date Deposited: 23 Jul 2010 11:13
Last Modified: 31 Mar 2016 13:28

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