JAK2(V617F) allele burden in polycythemia vera correlates with grade of myelofibrosis, but is not substantially affected by therapy
JAK2(V617F) allele burden in polycythemia vera correlates with grade of myelofibrosis, but is not substantially affected by therapy
In a series of 105 patients with polycythemia vera, we retrospectively determined whether the JAK2V617F mutation correlated with severity of disease phenotype. Higher JAK2V617F allele burden correlated with more advanced myelofibrosis, greater splenomegaly, and higher white blood cell count, but not with age, gender, hematocrit level, or frequency of phlebotomy prior to cytoreductive therapy. Although a subgroup at increased risk for thrombosis was not clearly defined, there was a suggestion that frequency of thrombosis increased as the JAK2V617F allele burden increased. The JAK2V617F allele burden did not change significantly in treated patients with serial JAK2 analyses.
myeloproliferative disorders, treatment of polycythemia vera, jak2(v617f) mutation, allele burden, splenomegaly, myelofibrosis
177-182
Silver, Richard T.
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Vandris, Katherine
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Wang, Y.Lynn
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Adriano, Fernando
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Jones, Amy V.
3d296088-a099-45cf-b227-541ff59d800c
Christos, Paul J.
96cfe9aa-78f7-4cb9-ab37-e08b2c531f57
Cross, Nicholas C.P.
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February 2011
Silver, Richard T.
661e0b91-4a5c-4100-9a7a-e4f1db3f3a1d
Vandris, Katherine
42852a40-1f83-4d34-bd50-78dd60d14335
Wang, Y.Lynn
61c22026-87e5-400b-93ea-172acf3edb35
Adriano, Fernando
e4ad50a6-b9db-453c-8b12-0e282d6f4fcd
Jones, Amy V.
3d296088-a099-45cf-b227-541ff59d800c
Christos, Paul J.
96cfe9aa-78f7-4cb9-ab37-e08b2c531f57
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Silver, Richard T., Vandris, Katherine, Wang, Y.Lynn, Adriano, Fernando, Jones, Amy V., Christos, Paul J. and Cross, Nicholas C.P.
(2011)
JAK2(V617F) allele burden in polycythemia vera correlates with grade of myelofibrosis, but is not substantially affected by therapy.
Leukemia Research, 35 (2), .
(doi:10.1016/j.leukres.2010.06.017).
(PMID:20650526)
Abstract
In a series of 105 patients with polycythemia vera, we retrospectively determined whether the JAK2V617F mutation correlated with severity of disease phenotype. Higher JAK2V617F allele burden correlated with more advanced myelofibrosis, greater splenomegaly, and higher white blood cell count, but not with age, gender, hematocrit level, or frequency of phlebotomy prior to cytoreductive therapy. Although a subgroup at increased risk for thrombosis was not clearly defined, there was a suggestion that frequency of thrombosis increased as the JAK2V617F allele burden increased. The JAK2V617F allele burden did not change significantly in treated patients with serial JAK2 analyses.
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Accepted/In Press date: 20 July 2010
Published date: February 2011
Keywords:
myeloproliferative disorders, treatment of polycythemia vera, jak2(v617f) mutation, allele burden, splenomegaly, myelofibrosis
Identifiers
Local EPrints ID: 161289
URI: http://eprints.soton.ac.uk/id/eprint/161289
ISSN: 0145-2126
PURE UUID: 80d8cbfc-d176-4256-a020-410a6a490cd8
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Date deposited: 27 Jul 2010 14:17
Last modified: 14 Mar 2024 02:46
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Contributors
Author:
Richard T. Silver
Author:
Katherine Vandris
Author:
Y.Lynn Wang
Author:
Fernando Adriano
Author:
Amy V. Jones
Author:
Paul J. Christos
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