Systematic reviews of diagnostic tests in cancer: review of methods and reporting


Mallett, Susan, Deeks, Jonathan J., Halligan, Steve, Hopewell, Sally, Cornelius, Victoria and Altman, Douglas G. (2006) Systematic reviews of diagnostic tests in cancer: review of methods and reporting. BMJ, 333, (7565), 413. (doi:10.1136/bmj.38895.467130.55).

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Description/Abstract

Objectives To assess the methods and reporting of systematic reviews of diagnostic tests.

Data sources Systematic searches of Medline, Embase, and five other databases identified reviews of tests used in patients with cancer. Of these, 89 satisfied our inclusion criteria of reporting accuracy of the test compared with a reference test, including an electronic search, and published since 1990.

Review methods All reviews were assessed for methods and reporting of objectives, search strategy, participants, clinical setting, index and reference tests, study design, study results, graphs, meta-analysis, quality, bias, and procedures in the review. We assessed 25 randomly selected reviews in more detail.

Results 75% (67) of the reviews stated inclusion criteria, 49% (44) tabulated characteristics of included studies, 40% (36) reported details of study design, 17% (15) reported on the clinical setting, 17% (15) reported on the severity of disease in participants, and 49% (44) reported on whether the tumours were primary, metastatic, or recurrent. Of the 25 reviews assessed in detail, 68% (17) stated the reference standard used in the review, 36% (9) reported the definition of a positive result for the index test, and 56% (14) reported sensitivity, specificity, and sample sizes for individual studies. Of the 89 reviews, 61% (54) attempted to formally synthesise results of the studies and 32% (29) reported formal assessments of study quality.

Conclusions Reliability and relevance of current systematic reviews of diagnostic tests is compromised by poor reporting and review methods.

Item Type: Article
ISSNs: 0959-535X (print)
0959-8146 (electronic)
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
H Social Sciences > HA Statistics
Divisions: University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
ePrint ID: 162303
Date Deposited: 18 Aug 2010 10:52
Last Modified: 27 Mar 2014 19:17
URI: http://eprints.soton.ac.uk/id/eprint/162303

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