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Immunochemical methods for the peptidomic analysis of tachykinin peptides and their precursors

Immunochemical methods for the peptidomic analysis of tachykinin peptides and their precursors
Immunochemical methods for the peptidomic analysis of tachykinin peptides and their precursors
The tachykinins represent the largest known peptide family and are responsible for a range of pleiotropic functions in both vertebrates and invertebrates. Recent research has shown a diversity of mechanisms such as mRNA splicing, precursor processing and post-translation modification that can lead to a complex and continually expanding repertoire of tachykinin peptides. The peptidomic analysis of the tachykinins has been hindered by the lack of specific methodologies to capture, purify and characterise each tachykinin. This chapter summarises some of the methods that have been developed in order to further purify and characterise individual groups of tachykinin peptides from the peptidome.
endokinin, hemokinin, tachykinin, antibody, immunoassay
293-312
Page, Nigel M
24429f0c-b7fb-47c0-9f7a-b714ed4d2ff4
Weston-Bell, Nicola J.
c99c8c28-519f-4c3e-bd8c-679995a0472e
Page, Nigel M
24429f0c-b7fb-47c0-9f7a-b714ed4d2ff4
Weston-Bell, Nicola J.
c99c8c28-519f-4c3e-bd8c-679995a0472e

Page, Nigel M and Weston-Bell, Nicola J. (2010) Immunochemical methods for the peptidomic analysis of tachykinin peptides and their precursors. Methods in Molecular Biology, 615, 293-312. (doi:10.1007/978-1-60761-535-4_22).

Record type: Article

Abstract

The tachykinins represent the largest known peptide family and are responsible for a range of pleiotropic functions in both vertebrates and invertebrates. Recent research has shown a diversity of mechanisms such as mRNA splicing, precursor processing and post-translation modification that can lead to a complex and continually expanding repertoire of tachykinin peptides. The peptidomic analysis of the tachykinins has been hindered by the lack of specific methodologies to capture, purify and characterise each tachykinin. This chapter summarises some of the methods that have been developed in order to further purify and characterise individual groups of tachykinin peptides from the peptidome.

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More information

Published date: 8 January 2010
Keywords: endokinin, hemokinin, tachykinin, antibody, immunoassay

Identifiers

Local EPrints ID: 162359
URI: http://eprints.soton.ac.uk/id/eprint/162359
PURE UUID: cd6ad659-dddd-4819-8edd-077d15ac8d5f
ORCID for Nicola J. Weston-Bell: ORCID iD orcid.org/0000-0003-0075-7276

Catalogue record

Date deposited: 19 Aug 2010 13:05
Last modified: 14 Mar 2024 02:02

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Contributors

Author: Nigel M Page
Author: Nicola J. Weston-Bell ORCID iD

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