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A study of bubble activity generated in ex-vivo tissue by high intensity focused ultrasound (HIFU)

A study of bubble activity generated in ex-vivo tissue by high intensity focused ultrasound (HIFU)
A study of bubble activity generated in ex-vivo tissue by high intensity focused ultrasound (HIFU)
Cancer treatment by extracorporeal high-intensity focused ultrasound (HIFU) is constrained by the time required to ablate clinically relevant tumour volumes. Although cavitation may be used to optimize HIFU treatments, its role during lesion formation is ambiguous. Clear differentiation is required between acoustic cavitation (noninertial and inertial) effects and bubble formation arising from two thermally-driven effects (the vapourization of liquid into vapour, and the exsolution of formerly dissolved permanent gas out of the liquid and into gas spaces). This study uses clinically relevant HIFU exposures in degassed water and ex vivo bovine liver to test a suite of cavitation detection techniques that exploit passive and active acoustics, audible emissions and the electrical drive power fluctuations. Exposure regimes for different cavitation activities (none, acoustic cavitation and, for ex vivo tissue only, acoustic cavitation plus thermally-driven gas space formation) were identified both in degassed water and in ex vivo liver using the detectable characteristic acoustic emissions. The detection system proved effective in both degassed water and tissue, but requires optimization for future clinical application.
active cavitation detection, ultrasonic acoustic emissions, b-mode, boiling, hifu, passive cavitation detection, drive power fluctuations, audible emissions
0301-5629
1327-1344
McLaughlan, James
67d90c91-797a-412b-98b5-41acaeffbc52
Rivens, Ian
21ac1940-a62b-429b-886e-9412e55a7ffd
Leighton, Timothy
3e5262ce-1d7d-42eb-b013-fcc5c286bbae
ter Haar, Gail
b7c05011-3bb9-4669-a049-4c22fc70f548
McLaughlan, James
67d90c91-797a-412b-98b5-41acaeffbc52
Rivens, Ian
21ac1940-a62b-429b-886e-9412e55a7ffd
Leighton, Timothy
3e5262ce-1d7d-42eb-b013-fcc5c286bbae
ter Haar, Gail
b7c05011-3bb9-4669-a049-4c22fc70f548

McLaughlan, James, Rivens, Ian, Leighton, Timothy and ter Haar, Gail (2010) A study of bubble activity generated in ex-vivo tissue by high intensity focused ultrasound (HIFU). Ultrasound in Medicine & Biology, 36 (8), 1327-1344. (doi:10.1016/j.ultrasmedbio.2010.05.011).

Record type: Article

Abstract

Cancer treatment by extracorporeal high-intensity focused ultrasound (HIFU) is constrained by the time required to ablate clinically relevant tumour volumes. Although cavitation may be used to optimize HIFU treatments, its role during lesion formation is ambiguous. Clear differentiation is required between acoustic cavitation (noninertial and inertial) effects and bubble formation arising from two thermally-driven effects (the vapourization of liquid into vapour, and the exsolution of formerly dissolved permanent gas out of the liquid and into gas spaces). This study uses clinically relevant HIFU exposures in degassed water and ex vivo bovine liver to test a suite of cavitation detection techniques that exploit passive and active acoustics, audible emissions and the electrical drive power fluctuations. Exposure regimes for different cavitation activities (none, acoustic cavitation and, for ex vivo tissue only, acoustic cavitation plus thermally-driven gas space formation) were identified both in degassed water and in ex vivo liver using the detectable characteristic acoustic emissions. The detection system proved effective in both degassed water and tissue, but requires optimization for future clinical application.

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More information

Published date: August 2010
Keywords: active cavitation detection, ultrasonic acoustic emissions, b-mode, boiling, hifu, passive cavitation detection, drive power fluctuations, audible emissions

Identifiers

Local EPrints ID: 162573
URI: http://eprints.soton.ac.uk/id/eprint/162573
ISSN: 0301-5629
PURE UUID: 636257b6-cd51-40db-95bb-fc718c2a3969
ORCID for Timothy Leighton: ORCID iD orcid.org/0000-0002-1649-8750

Catalogue record

Date deposited: 24 Aug 2010 10:34
Last modified: 14 Mar 2024 02:37

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Contributors

Author: James McLaughlan
Author: Ian Rivens
Author: Gail ter Haar

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