The relative role of peripheral blood and bone marrow for monitoring molecular evidence of disease in follicular lymphoma by quantitative real-time polymerase chain reaction


Summers, Karin E., Davies, Andrew J., Matthews, Janet, Jenner, Michael J., Cornelius, Victoria, Amess, John A., Norton, Andrew J., Rohatiner, Ama Z.S., Fitzgibbon, Jude, Lister, Andrew T. and Goff, Lindsey K. (2002) The relative role of peripheral blood and bone marrow for monitoring molecular evidence of disease in follicular lymphoma by quantitative real-time polymerase chain reaction. British Journal of Haematology, 118, (2), 563-566. (doi:10.1046/j.1365-2141.2002.03641.x).

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Description/Abstract

Peripheral blood (PB) and bone marrow (BM) are used interchangeably for t(14;18) (IgH/BCL-2) molecular monitoring in follicular lymphoma (FL) and detection of rearrangement after treatment has been correlated to increased risk of relapse. To determine the relative value of each tissue, MBR t(14;18) was quantified by real-time polymerase chain reaction in 52 simultaneous paired PB and BM samples from 38 FL patients. In total, 79% of sample pairs taken in remission (n = 19) or when no morphological disease was evident in the BM (n = 29) had t(14;18) copy number within one log difference and the median difference was small. These findings suggest that, in remission, PB may be adequately monitored. In general, however, higher copy number was detected in BM than in the corresponding PB sample

Item Type: Article
ISSNs: 0007-1048 (print)
1365-2141 (electronic)
Related URLs:
Keywords: t(14;18), follicular lymphoma, real-time pcr, monitoring, quantification
Subjects: R Medicine > RB Pathology
Q Science > QR Microbiology > QR355 Virology
Q Science > QR Microbiology > QR180 Immunology
Divisions: University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
ePrint ID: 162635
Date Deposited: 25 Aug 2010 09:14
Last Modified: 27 Mar 2014 19:17
URI: http://eprints.soton.ac.uk/id/eprint/162635

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