Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics
Delivani, Petrina, Adrain, Colin, Taylor, Rebecca C., Duriez, Patrick J. and Martin, Seamus J. (2006) Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics. Molecular cell, 21, (6), 761-773. (doi:10.1016/j.molcel.2006.01.034). (PMID:16543141).
Download
Full text not available from this repository.
Description/Abstract
Bcl-2 family proteins play central roles in apoptosis by regulating the release of mitochondrial intermembrane space proteins such as cytochrome c. Death-promoting Bcl-2 family members, such as Bax, can promote cytochrome c release and fragmentation of the mitochondrial network, whereas apoptosis-inhibitory members, such as Bcl-2 and Bcl-xL, can antagonize these events. It remains unclear whether CED-9, the worm Bcl-2 relative, can regulate mitochondrial fission/fusion dynamics or the release of proteins from the mitochondrial intermembrane space. Here, we show that CED-9 interacts with Mitofusin-2/fuzzy onions and can promote mitochondrial clustering and dramatic reorganization of mitochondrial networks. Consistent with its ability to neutralize CED-9 function, EGL-1 antagonized CED-9-dependent remodeling of the mitochondrial network. However, CED-9 failed to inhibit mitochondrial cytochrome c release or apoptosis induced by diverse triggers in mammalian cells. These data suggest that the ability to regulate mitochondrial fission/fusion dynamics is an evolutionarily conserved property of the Bcl-2 family.
| Item Type: | Article |
|---|---|
| ISSNs: | 1097-2765 (print) 1097-4164 (electronic) |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 164799 |
| Date Deposited: | 04 Oct 2010 14:48 |
| Last Modified: | 01 Jun 2011 05:38 |
| Contributors: | Delivani, Petrina (Author) Adrain, Colin (Author) Taylor, Rebecca C. (Author) Duriez, Patrick J. (Author) Martin, Seamus J. (Author) |
| Date: | 17 March 2006 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/164799 |
Actions (login required)
 |
View Item |
