Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics
Delivani, Petrina, Adrain, Colin, Taylor, Rebecca C., Duriez, Patrick J. and Martin, Seamus J. (2006) Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics. Molecular cell, 21, (6), 761-773. (doi:10.1016/j.molcel.2006.01.034). (PMID:16543141).
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Bcl-2 family proteins play central roles in apoptosis by regulating the release of mitochondrial intermembrane space proteins such as cytochrome c. Death-promoting Bcl-2 family members, such as Bax, can promote cytochrome c release and fragmentation of the mitochondrial network, whereas apoptosis-inhibitory members, such as Bcl-2 and Bcl-xL, can antagonize these events. It remains unclear whether CED-9, the worm Bcl-2 relative, can regulate mitochondrial fission/fusion dynamics or the release of proteins from the mitochondrial intermembrane space. Here, we show that CED-9 interacts with Mitofusin-2/fuzzy onions and can promote mitochondrial clustering and dramatic reorganization of mitochondrial networks. Consistent with its ability to neutralize CED-9 function, EGL-1 antagonized CED-9-dependent remodeling of the mitochondrial network. However, CED-9 failed to inhibit mitochondrial cytochrome c release or apoptosis induced by diverse triggers in mammalian cells. These data suggest that the ability to regulate mitochondrial fission/fusion dynamics is an evolutionarily conserved property of the Bcl-2 family.
|Digital Object Identifier (DOI):||doi:10.1016/j.molcel.2006.01.034|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||04 Oct 2010 14:48|
|Last Modified:||27 Mar 2014 19:18|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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